---
title: "Naltrexone side effects: common and serious"
description: "Naltrexone side effects are often nausea, headache, and sleep changes, but rare serious liver injury and opioid withdrawal can occur. Know when to call."
canonical: "https://www.vitalsvault.com/treatment-learn/naltrexone-side-effects"
last-updated: 2026-08-22
---

# Naltrexone side effects: common and serious

> Naltrexone side effects are often nausea, headache, and sleep changes, but rare serious liver injury and opioid withdrawal can occur. Know when to call.

---

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