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Cialis 100mg side effects: what to expect

Cialis 100mg side effects range from headache and flushing to rare emergencies like priapism and sudden vision or hearing loss. Know when to get help.

Written by Vitals Vault Medical TeamMedically reviewed by Robert Lufkin, MD, Chief Medical Officer and Arti Chandra, MD, MPH, IFMCP, Board-certified in family and integrative medicine
Published September 30, 2026

Key facts

Price
Tadalafil Daily is $129/month (billed $387 every 90 days), charged only after a clinician approves it.
How it works
Answer a few health questions online. A licensed clinician reviews them. If approved, it ships to your door.
Who can get it
Adults 18 or older. A licensed clinician reviews your health history and decides whether treatment is appropriate for you. Availability depends on the state you live in.

Medically reviewed by Robert Lufkin, MD and Arti Chandra, MD, MPH, IFMCP

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Table of Contents

  1. 1Quick answer
  2. 2Side effects and safety details
  3. 3When to talk to a clinician
  4. 4Pro tips
  5. 5Related

Table of Contents

  1. 1Quick answer
  2. 2Side effects and safety details
  3. 3When to talk to a clinician
  4. 4Pro tips
  5. 5Related

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Cialis (tadalafil) is a prescription PDE5 inhibitor used for erectile dysfunction (ED) and, at different dosing, symptoms of benign prostatic hyperplasia (BPH). If you are searching for cialis 100mg side effects, the most important thing to know is that most side effects are mild, but a few rare ones are emergencies. This guide explains common versus serious tadalafil side effects, what tends to make them more likely, and when to call a clinician.

  • Cialis 100mg can cause side effects, and some require urgent care.
  • Common effects include headache, flushing, indigestion, back pain, and muscle aches.
  • Serious risks include priapism, sudden vision loss, sudden hearing loss, and low blood pressure with nitrates.
  • Do not use tadalafil with any nitrate medication; ask your clinician about all heart medicines.
  • If erection lasts over 4 hours, get emergency care to prevent permanent injury.

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Cialis 100mg side effects: the quick answer

What you should know first

Cialis (tadalafil) side effects are often related to blood vessel widening and smooth muscle relaxation. Many people notice headache, flushing, indigestion, or back and muscle pain, while rare but serious risks include priapism (erection over 4 hours), sudden vision loss, sudden hearing loss, and dangerous low blood pressure with nitrates.

Side effects and safety details (common vs serious)

  • Headache

    Headache is one of the most commonly reported tadalafil side effects. It is thought to be related to blood vessel dilation. If headaches are severe, recurrent, or come with neurologic symptoms, contact a clinician to review other causes and medication interactions.

  • Flushing and nasal congestion

    You may notice facial warmth or redness and a stuffy nose. These effects are consistent with PDE5 inhibitor related vasodilation. If you feel faint, have chest pain, or symptoms of low blood pressure, seek urgent evaluation.

  • Indigestion (dyspepsia)

    Some people get stomach upset or heartburn like symptoms. This can happen because tadalafil can relax smooth muscle in the gastrointestinal tract. Persistent or severe symptoms should be discussed with a clinician, especially if you also use reflux medicines or have ulcer history.

  • Back pain and muscle aches

    Back pain and muscle aches can occur with tadalafil and may start after dosing and resolve over time. If pain is severe, persistent, or associated with weakness, numbness, fever, or dark urine, contact a clinician promptly to rule out other problems.

  • Priapism (erection over 4 hours)

    Priapism is a prolonged erection that does not go away and can permanently damage penile tissue. This is a medical emergency. Get emergency care right away if an erection lasts more than 4 hours, whether or not it is painful.

  • Sudden vision or hearing loss

    Rarely, PDE5 inhibitors have been associated with sudden decrease or loss of vision (including NAION, nonarteritic anterior ischemic optic neuropathy) or sudden decrease or loss of hearing, sometimes with ringing in the ears or dizziness. Stop sexual activity and seek urgent medical evaluation if these occur.

  • Dangerous interaction with nitrates

    Do not take tadalafil with any nitrate medication (for example nitroglycerin) because the combination can cause a severe drop in blood pressure. This includes nitrates used for chest pain and some recreational products called poppers. If you have chest pain after taking tadalafil, tell emergency clinicians you took it.

  • Low blood pressure with alpha blockers

    Tadalafil can lower blood pressure, and the risk of dizziness or fainting can increase when combined with alpha blockers used for prostate symptoms or blood pressure. A clinician can help coordinate timing and dosing and monitor for symptoms, especially when starting or changing either medication.

  • Heart and chest symptoms during sex

    Sexual activity increases cardiac workload. If you develop chest pain, dizziness, or nausea during sex, stop and get medical help. People with certain heart conditions may be advised not to use PDE5 inhibitors or not to engage in sexual activity until cleared by a clinician.

  • Allergic reactions

    Serious allergic reactions are uncommon but can include rash, hives, swelling of the face or throat, or trouble breathing. Seek emergency care for breathing difficulty or swelling. Report any new rash or swelling to a clinician before taking another dose.

When to call a clinician or seek urgent care

  • Go to the ER now

    Get emergency care for an erection lasting more than 4 hours, chest pain, fainting, severe shortness of breath, or sudden vision or hearing loss. These can signal rare but serious complications where delays can lead to permanent harm.

  • Call a clinician soon

    Contact a clinician if side effects are severe, keep recurring, or interfere with daily life, including persistent headache, significant dizziness, or ongoing back or muscle pain. Also call if you start any new heart or blood pressure medicine, or if you think you may have taken a nitrate.

  • Discuss ED as a health signal

    Erectile dysfunction can be an early sign of cardiovascular disease, diabetes, sleep apnea, low testosterone, medication side effects, or depression. If ED is new or worsening, ask about a broader evaluation rather than only changing ED medication.

Do not mix with nitrates

Tadalafil must not be used with nitrate medications because of the risk of severe low blood pressure. If you are unsure whether a medicine contains a nitrate, ask a pharmacist or prescribing clinician before taking tadalafil.

Pro tips to reduce risk

  • Bring a full med list

    Include nitrates, alpha blockers, blood pressure drugs, and supplements when you ask about tadalafil.

  • Avoid recreational nitrates

    Products called poppers can contain nitrates and are unsafe with tadalafil.

  • Check for red flags

    Vision or hearing changes, fainting, or erection over 4 hours needs urgent evaluation.

  • Talk about heart health

    If ED is new, ask whether you should be screened for cardiovascular risk factors.

Related treatments

Cialis Side EffectsTake Cialis Avoid Side Effects ResultsIs Tadalafil The Same As CialisCialis TadalafilTadalafil Cialis Medicare Coverage
Tadalafil Daily

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  1. 1Answer a few health questions
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  3. 3If approved, it ships to your door

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Tadalafil Daily is $387 per 90-day supply, charged only after a clinician approves it.

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Frequently Asked Questions

What is Cialis used for?

Cialis (tadalafil) is used to treat erectile dysfunction (ED) and, at different dosing, signs and symptoms of benign prostatic hyperplasia (BPH). Some people may also be prescribed tadalafil for pulmonary arterial hypertension under a different brand, but dosing and monitoring differ.

Is cialis 100mg safe?

Safety depends on your health history, other medications, and the dose you are prescribed. Tadalafil can be dangerous if taken with nitrates and can rarely cause emergencies like priapism or sudden vision or hearing loss. A clinician should review your risks before you use it.

What should I do if I get chest pain after taking tadalafil?

Stop sexual activity and seek emergency care right away. Tell emergency clinicians you took tadalafil, because nitrates used for chest pain can cause a severe blood pressure drop when combined with tadalafil. Do not self treat chest pain at home.

Can Cialis cause vision problems?

Rarely, PDE5 inhibitors including tadalafil have been associated with sudden decrease or loss of vision, including NAION. If you notice sudden vision changes, stop sexual activity and get urgent medical evaluation. Discuss any prior eye disease with your clinician before using tadalafil.

How can Vitals Vault help if I am having ED symptoms?

Vitals Vault can help you start with labs to check for common contributors to ED and share results with a clinician. If treatment is appropriate, a licensed clinician reviews your history and can discuss options that include ongoing support. Severe or sudden symptoms need urgent care, not a lab order.

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