Cardio IQ ASCVD Risk Panel With Score
It estimates your 10-year ASCVD risk using advanced lipids and key markers, with convenient ordering and Quest-based lab collection through Vitals Vault.
This panel bundles multiple biomarker tests in one order—your report explains how results fit together.
This panel is designed to answer a practical question: what is your risk of atherosclerotic cardiovascular disease (ASCVD), and what parts of your cholesterol story might be missed by a basic lipid panel.
Instead of focusing only on LDL cholesterol (LDL-C), it typically adds “advanced lipid” measures such as apolipoprotein B (ApoB) and LDL particle information, plus inflammation and metabolic markers that can shift risk in either direction.
Your score is not a diagnosis. It is a structured way to combine lab data with clinical context so you and your clinician can decide whether lifestyle changes, medication, or follow-up testing makes sense.
Do I need a Cardio IQ ASCVD Risk Panel With Score test?
You might consider this test if you want a more complete cardiovascular risk picture than a standard cholesterol panel provides. It is especially useful when your LDL-C looks “fine,” but you have a strong family history of early heart disease, metabolic risk (such as insulin resistance), or prior abnormal lipids.
This panel can also be helpful if you are deciding whether to start or intensify lipid-lowering therapy, or if you are already on treatment and want to confirm that the markers most closely tied to plaque risk (like ApoB or LDL particle measures) are improving.
You may also benefit if your triglycerides are elevated, your HDL is low, you have fatty liver concerns, you smoke, you have high blood pressure, or you are postmenopausal—because these factors can change risk even when total cholesterol is not dramatic.
If you have chest pain, shortness of breath, or symptoms that could be an emergency, you should seek urgent medical care. This test supports clinician-directed prevention planning; it is not meant for self-diagnosis or to rule out an acute cardiac event.
This is a laboratory-developed panel run in a CLIA-certified lab; results should be interpreted with your clinician alongside your history, medications, and other risk factors.
Lab testing
Order labs to measure Cardio IQ ASCVD Risk Panel with Score
from $32.99 at Quest Diagnostics
About 1 week
Schedule online — results typically within a week
Clear next steps
Guidance included, with follow-up care available
HSA / FSA
Eligible for pre-tax health spending accounts
Get this test with Vitals Vault
Vitals Vault lets you order the Cardio IQ ASCVD Risk Panel With Score without needing to schedule a separate doctor visit just to access labs. You complete checkout, then visit a participating lab location for a blood draw.
Once your results are back, you can use PocketMD to translate the numbers into next steps to discuss with your clinician—such as which markers to prioritize, what changes are most likely to move them, and when retesting is reasonable.
If your results suggest you need broader context (for example, thyroid function, kidney function, or glucose/insulin patterns), you can map follow-up testing in the same place and track trends over time.
- Order online and complete your blood draw at a local lab location
- Clear, plain-language guidance in PocketMD for follow-up planning
- Designed for trending: compare results across retests and treatment changes
Key benefits of Cardio IQ ASCVD Risk Panel With Score testing
- Gives a more complete risk snapshot than LDL-C alone by adding advanced lipid measures.
- Helps identify “hidden” risk when LDL-C is normal but ApoB or particle measures are high.
- Adds context from inflammation and metabolic markers that can raise or lower ASCVD risk.
- Supports more targeted conversations about statins, non-statin therapy, and lifestyle priorities.
- Improves monitoring by showing whether treatment is lowering the atherogenic particle burden.
- Can clarify risk in people with family history of early heart disease or mixed lipid patterns.
- Pairs well with PocketMD so you can turn results into a practical retest and follow-up plan.
What is the Cardio IQ ASCVD Risk Panel With Score?
The Cardio IQ ASCVD Risk Panel With Score is a blood test bundle that combines cholesterol-related markers with additional risk indicators to estimate your likelihood of developing atherosclerotic cardiovascular disease. ASCVD refers to plaque buildup in arteries that can lead to heart attack, stroke, or peripheral artery disease.
A standard lipid panel reports total cholesterol, LDL-C, HDL-C, and triglycerides. This panel typically goes further by measuring markers that better reflect the number of atherogenic particles circulating in your blood (for example, ApoB and LDL particle measures). It may also include lipoprotein(a) (Lp(a)), an inherited risk factor, and high-sensitivity C-reactive protein (hs-CRP), a marker of inflammation.
The “with score” component means the lab report may provide a calculated risk estimate using a validated equation that incorporates your lab values and clinical inputs (such as age and sex). Your clinician may compare that estimate with guideline-based risk categories and your personal risk enhancers (family history, Lp(a), diabetes, smoking, blood pressure) to decide what to do next.
Why advanced lipids matter
LDL-C is the amount of cholesterol carried inside LDL particles, but it does not always match how many LDL (and other ApoB-containing) particles you have. If you have many small cholesterol-poor particles, your LDL-C can look acceptable while your particle number and ApoB are elevated, which may better track plaque risk.
What the ASCVD score can and cannot do
A risk score is a decision aid, not a guarantee. It estimates probability over time for groups of people, and it can under- or over-estimate risk for an individual depending on genetics, inflammation, kidney disease, ethnicity, and other factors. Your best use of the score is to guide preventive intensity and retesting intervals.
What do my Cardio IQ ASCVD Risk Panel With Score results mean?
Low-risk or lower-than-expected results
If your score and advanced lipid markers are low, it generally suggests a lower near-term risk of ASCVD compared with peers of the same age and sex. Low ApoB and favorable LDL particle measures usually mean fewer atherogenic particles are available to enter the artery wall. Even with reassuring results, your long-term risk still depends on blood pressure, smoking status, activity, sleep, and family history. Many people use a low-risk result to confirm that current habits are working and to set a reasonable retest cadence.
Optimal or in-range results
An in-range panel usually means your traditional lipids and advanced markers are aligned and do not show major hidden risk. In this situation, the most useful question becomes whether your results match your personal risk profile—for example, whether a strong family history or elevated Lp(a) suggests you should aim for more aggressive targets. Your clinician may focus on maintaining blood pressure control, keeping triglycerides in check, and monitoring over time rather than making immediate medication changes.
High-risk or higher-than-expected results
A higher ASCVD risk score and/or elevated atherogenic markers (often ApoB, LDL particle number, or Lp(a)) suggests a higher probability of plaque development over time. This does not mean you have a blockage today, but it does raise the value of preventive action. Your clinician may discuss intensifying lifestyle changes, starting or adjusting lipid-lowering therapy, and checking for related drivers such as insulin resistance, hypothyroidism, or kidney disease. If inflammation markers are high, the next step is often to look for common causes (infection, chronic inflammatory conditions, smoking, excess visceral fat) before assuming it is “heart inflammation.”
Factors that influence your panel
Diet, weight change, alcohol intake, and recent illness can shift triglycerides and inflammation markers, which can affect risk estimates. Medications such as statins, ezetimibe, PCSK9 inhibitors, hormone therapy, and some diabetes drugs can substantially change lipid fractions and particle measures. Genetics strongly influence Lp(a), and lifestyle changes usually have limited impact on it even when other markers improve. Fasting status and timing can matter for triglycerides and calculated LDL-C, so follow your lab’s prep instructions and try to retest under similar conditions.
What’s included
- 10 Year Ascvd Risk
- Lifetime Ascvd Risk
- Cholesterol, Total
- Hdl Cholesterol
- Triglycerides
- Ldl-Cholesterol
- Chol/Hdlc Ratio
- Non Hdl Cholesterol
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Frequently Asked Questions
Do I need to fast for the Cardio IQ ASCVD Risk Panel With Score?
Many clinicians prefer a fasting sample (often 9–12 hours) because triglycerides can rise after meals and can affect calculated LDL-C and some derived values. If your order instructions say fasting, follow them, and try to retest under similar conditions for cleaner trend comparisons.
What is an ASCVD risk score, and what does it predict?
An ASCVD risk score is a calculated estimate of your probability of having a cardiovascular event over a defined time window (commonly 10 years). It uses population data and inputs such as age, sex, cholesterol values, and sometimes other factors. It helps guide prevention decisions, but it does not diagnose plaque or predict exactly what will happen to you personally.
How is this different from a standard lipid panel?
A standard lipid panel focuses on cholesterol amounts (LDL-C, HDL-C, triglycerides). This panel typically adds advanced markers like ApoB, LDL particle measures, Lp(a), and sometimes hs-CRP, which can reveal risk that LDL-C alone can miss—especially in insulin resistance, high triglycerides, or strong family history.
What does ApoB tell me that LDL cholesterol doesn’t?
ApoB is a proxy for the number of atherogenic particles (LDL, VLDL remnants, and others) that can enter the artery wall. Two people can have the same LDL-C but different ApoB, meaning one person may have more particles and potentially higher risk. ApoB is often used to monitor whether therapy is reducing particle burden.
If my Lp(a) is high, can I lower it with diet and exercise?
Lp(a) is largely genetic, so lifestyle changes usually do not lower it much. However, lifestyle can still improve other modifiable risks (blood pressure, ApoB, triglycerides, inflammation), which matters even more when Lp(a) is elevated. Your clinician may discuss more aggressive LDL/ApoB targets and whether additional therapies or imaging are appropriate.
How often should I retest this panel?
Retest timing depends on what you are changing. After starting or adjusting lipid-lowering therapy, many clinicians recheck key lipids in about 6–12 weeks, then space out once stable. If you are making lifestyle changes only, a 3–6 month interval is common to see a meaningful shift, unless your clinician recommends sooner due to higher risk.
Can inflammation or a cold affect my hs-CRP result?
Yes. hs-CRP can rise with infections, injuries, dental issues, and chronic inflammatory conditions. If your hs-CRP is unexpectedly high and you were recently sick, your clinician may suggest repeating it when you are well to better reflect baseline cardiovascular inflammation.