Hickory Pecan Tree T22 IgG Biomarker Testing
It measures IgG antibodies to hickory/pecan tree (T22) proteins to support exposure tracking, with easy ordering and results via Vitals Vault/Quest.
With Vitals Vault, you have access to a comprehensive range of biomarker tests.
A Hickory Pecan Tree T22 IgG test measures your IgG antibodies to proteins from hickory/pecan tree sources (often grouped as a “tree” antigen). People usually order it when they are trying to map patterns between exposures and symptoms, or when they are comparing different types of allergy and sensitivity testing.
This result is easy to misread if you expect it to work like a classic allergy test. IgG can reflect immune recognition and prior exposure, but it does not automatically mean you have an immediate-type allergy, and it does not prove that a specific symptom is caused by this trigger.
Used well, the test can help you and your clinician ask better follow-up questions: Is this a one-off finding or a stable pattern? Does it match your seasonality, environment, or diet? And do you need IgE testing or other clinical evaluation to clarify risk?
Do I need a Hickory Pecan Tree T22 IgG test?
You might consider this test if you are trying to understand whether your immune system has been reacting to hickory/pecan tree–related exposures and you want an objective data point to compare with your history. This often comes up when symptoms feel “patterned” but hard to pin down, such as recurring congestion, throat irritation, cough, headaches, skin flares, or fatigue that seems to track with certain environments or seasons.
It can also be useful if you already have a broader IgG panel and you are narrowing down which individual items are driving the strongest signals, or if you want to retest after a period of reduced exposure to see whether your antibody level trends down over time.
You may not need this test if your main concern is immediate allergy risk (hives, wheeze, anaphylaxis, rapid swelling). In those situations, allergen-specific IgE testing and clinician-directed evaluation are typically more appropriate.
Testing is most helpful when it supports a clinician-guided plan rather than self-diagnosis, especially if you have asthma, severe reactions, or complex multi-trigger symptoms.
This is a laboratory-developed test performed in a CLIA-certified lab; results support clinical decision-making but are not, by themselves, a diagnosis of allergy or disease.
Lab testing
Order labs to measure Hickory/Pecan Tree (t22) IgG
from $105.19 at Quest Diagnostics
About 1 week
Schedule online — results typically within a week
Clear next steps
Guidance included, with follow-up care available
HSA / FSA
Eligible for pre-tax health spending accounts
Get this test with Vitals Vault
Vitals Vault lets you order Hickory Pecan Tree T22 IgG testing without needing to coordinate a separate lab requisition visit. After you order, you can complete your blood draw through the Quest network and view your results in one place.
Once your result is back, PocketMD can help you interpret what “low,” “in range,” or “high” means in plain language and how to think about next steps, like whether an IgE test, a broader allergen panel, or a structured exposure diary would add clarity.
If you are tracking changes, you can also use Vitals Vault to reorder and compare trends over time, which is often more informative than a single snapshot—especially for immune markers that can fluctuate with season, infections, and recent exposure.
- Order online and draw at Quest locations
- PocketMD guidance for next-step questions to discuss with your clinician
- Easy retesting to track trends over time
Key benefits of Hickory Pecan Tree T22 IgG testing
- Adds an objective data point when you suspect hickory/pecan tree exposure may be part of a symptom pattern.
- Helps distinguish “immune recognition” (IgG) from immediate-type allergy questions that are better answered with IgE testing.
- Supports elimination or exposure-reduction trials by giving you a baseline to compare against later retesting.
- Can help prioritize which triggers to investigate first when you have many possible environmental or dietary exposures.
- Provides a way to track whether antibody levels trend down after seasonal changes or reduced exposure.
- Improves conversations with your clinician by pairing symptoms and timing with a measurable lab result.
- Fits into a broader lab-mapping approach when combined with other allergen markers and clinical history.
What is Hickory Pecan Tree T22 IgG?
Hickory Pecan Tree T22 IgG is a blood test that measures immunoglobulin G (IgG) antibodies directed at proteins associated with hickory/pecan tree sources (reported as the T22 allergen code in many lab catalogs). IgG is one of the main antibody classes your immune system uses to recognize and “remember” exposures.
Unlike immunoglobulin E (IgE), which is more closely linked to immediate allergic reactions, IgG is often interpreted as a marker of exposure and immune response over time. A higher IgG level can mean your immune system has been seeing this antigen more often, but it does not automatically mean the exposure is harmful or that it is the cause of your symptoms.
Because symptoms can overlap across many triggers, this test is usually most useful when you interpret it alongside your real-world context: where you live, seasonal patterns, occupational or hobby exposures, diet, and any other allergic or inflammatory conditions you have.
IgG vs IgE: why the distinction matters
If you are worried about rapid reactions (for example, hives within minutes, wheezing, or swelling), IgE testing and clinician evaluation are the safer and more direct tools. IgG results are not designed to predict immediate reaction risk, and a “high IgG” should not be treated as proof that you are allergic in the classic sense.
What the test does not prove
This test does not confirm a diagnosis of allergic rhinitis, asthma, food allergy, or mast cell disorders. It also cannot, on its own, tell you whether avoidance will improve symptoms. It is best used as one piece of evidence to guide a structured plan and follow-up testing when needed.
What do my Hickory Pecan Tree T22 IgG results mean?
Low Hickory Pecan Tree T22 IgG
A low result generally means your immune system shows little measurable IgG recognition of this antigen at the time of testing. This can happen if you have minimal exposure, if exposure was remote in time, or if your immune response to this specific antigen is simply not strong. A low IgG result does not rule out symptoms from other triggers, and it does not rule out an IgE-mediated allergy if your history suggests rapid reactions.
In-range (typical) Hickory Pecan Tree T22 IgG
An in-range result is commonly interpreted as no strong IgG signal beyond what the lab considers typical for this assay. If you feel well, this is usually reassuring. If you have symptoms, an in-range IgG result often shifts the focus to other exposures, other allergens, or non-allergic causes (such as irritant exposure, infections, reflux, or chronic sinus issues), depending on your situation.
High Hickory Pecan Tree T22 IgG
A high result means you have a stronger IgG antibody signal to this antigen than the lab’s reference threshold. The most common interpretation is increased immune recognition, which may reflect more frequent or more recent exposure. It does not automatically mean the exposure is harmful, and it does not confirm that this trigger is causing your symptoms, so it is best used to guide a careful trial (for example, exposure reduction and symptom tracking) or to decide whether IgE testing is warranted.
Factors that influence Hickory Pecan Tree T22 IgG
Recent and repeated exposure can raise IgG levels, while reduced exposure over time may allow levels to drift down. Seasonality, geography, and indoor air factors (ventilation, filtration, humidity, and time spent outdoors) can change your exposure profile. Immune activity can also shift after infections, during periods of high inflammation, or with certain medications that affect immune function. Different labs and methods may use different reporting scales, so comparing results is most reliable when you use the same lab over time.
What’s included
- Hickory/Pecan Tree (T22) Igg
Similar tests to consider
Frequently Asked Questions
Is Hickory Pecan Tree T22 IgG an allergy test?
It is an immune response test, but it is not the same as an immediate-type allergy test. IgG reflects immune recognition and exposure patterns, while allergen-specific IgE is more directly tied to classic allergy reactions. If you have rapid symptoms after exposure, discuss IgE testing with your clinician.
Do I need to fast for a Hickory Pecan Tree T22 IgG blood test?
Fasting is not usually required for an IgG antibody test. If you are combining it with other labs (like lipids or glucose), follow the fasting instructions for the full set of tests you ordered.
What does a high T22 IgG level mean?
A high result means your IgG antibody signal to hickory/pecan tree antigen is above the lab’s reference threshold. It often suggests more immune recognition or more recent/frequent exposure, but it does not prove you have a clinical allergy or that this exposure is the cause of your symptoms.
How soon should I retest IgG after avoiding an exposure?
Many people wait several weeks to a few months to look for meaningful trend changes, because antibody levels do not always shift quickly. The best timing depends on your exposure pattern (seasonal vs year-round) and what decision you are trying to make, so it helps to set a retest window with your clinician.
Can IgG testing diagnose food sensitivities or environmental triggers?
IgG testing can support hypothesis-building, but it does not diagnose a sensitivity on its own. The most useful approach is to pair the result with symptom timing, a structured exposure or elimination trial, and follow-up testing (often IgE or other evaluations) when the clinical picture calls for it.
Why are my symptoms strong if my IgG result is normal?
Symptoms can be driven by many factors that IgG testing does not measure, including IgE-mediated allergy, irritant exposure, infections, asthma, reflux, or non-allergic inflammation. A normal IgG result can be a clue to look elsewhere rather than a statement that your symptoms are not real.