Hake F307 IgE (Fish Allergy) Biomarker Testing
It measures IgE sensitization to hake fish to help assess allergy risk and next steps, with convenient ordering through Vitals Vault and Quest labs.
With Vitals Vault, you have access to a comprehensive range of biomarker tests.
A Hake F307 IgE test is a blood test that looks for allergic-type antibodies (IgE) directed at proteins from hake, a commonly eaten white fish.
This test does not diagnose a food allergy by itself. It helps you and your clinician estimate the likelihood that your immune system is sensitized to hake and decide whether avoidance, additional testing, or a supervised food challenge makes sense.
Because fish allergy can overlap across species, your result is most useful when it is interpreted alongside your reaction history and, when appropriate, other seafood IgE tests.
Do I need a Hake F307 IgE test?
You may want a Hake F307 IgE test if you have symptoms that happen soon after eating hake or a mixed seafood meal. Common patterns include hives, itching, lip or throat swelling, wheezing, coughing, vomiting, or sudden abdominal pain within minutes to a couple of hours after exposure.
Testing can also be helpful if you have had a concerning reaction to “white fish” but you are not sure which species triggered it, or if you are trying to clarify whether you can safely eat certain fish while avoiding others.
If you have had a severe reaction (trouble breathing, fainting, or needing epinephrine), do not use a lab result to decide on re-exposure. Use the test to support clinician-directed care, including an emergency action plan and decisions about additional evaluation.
This is typically a CLIA-certified laboratory blood test for allergen-specific IgE; results support risk assessment but are not a standalone diagnosis of food allergy.
Lab testing
Order Hake F307 IgE through Vitals Vault and complete your draw at a Quest location.
Schedule online, results typically within about a week
Clear reporting and optional clinician context
HSA/FSA eligible where applicable
Get this test with Vitals Vault
Vitals Vault lets you order a Hake F307 IgE blood test without needing a separate lab visit to request it. After you order, you can complete your draw at a participating Quest location.
Once your result is back, you can use PocketMD to put the number into context with your symptoms, timing of reactions, and any related results you already have. That is especially useful for fish allergy questions, where the same IgE level can mean different things depending on your history.
If your situation changes, you can also use Vitals Vault to retest or broaden your workup with companion allergy testing so you are not making decisions based on a single data point.
- Order online and draw at a Quest location
- PocketMD helps you prepare follow-up questions for your clinician
- Easy retesting to track changes over time
Key benefits of Hake F307 IgE testing
- Helps identify whether your immune system is sensitized to hake fish proteins (allergen-specific IgE).
- Adds objective data when your reaction history is unclear or meals included multiple seafood ingredients.
- Supports safer planning around avoidance, label reading, and cross-contact risk in restaurants.
- Helps your clinician decide whether additional seafood IgE tests or skin testing are worth doing.
- Can guide whether a supervised oral food challenge might be appropriate when results and symptoms do not match.
- Provides a baseline value you can compare over time if your clinician recommends retesting.
- Pairs well with PocketMD so you can interpret the result in context instead of guessing from the number alone.
What is Hake F307 IgE?
Hake F307 IgE is a “specific IgE” blood test that measures how much IgE antibody in your blood binds to hake (an allergen extract associated with the ImmunoCAP code f307 in many lab systems). IgE is the antibody class involved in immediate-type allergic reactions.
A positive result means sensitization: your immune system recognizes hake proteins and has made IgE against them. Sensitization increases the likelihood of an allergic reaction, but it does not guarantee you will react every time or that a reaction will be severe.
Your clinician typically interprets this test using three inputs: your symptom history (what happened and how quickly), your exposure (how much you ate and whether it was cooked), and your test result (how strongly IgE binds).
Sensitization vs. clinical allergy
Clinical allergy means you reliably develop symptoms when you are exposed. Sensitization means your immune system has IgE that recognizes the food, but you may or may not have symptoms in real life. This is why your history matters as much as the lab value.
Why fish allergy can be complicated
Some people react to multiple fish species because of shared proteins (often parvalbumin), while others react to only one or a few. Cross-contact during processing or cooking can also trigger symptoms even when you did not intentionally eat the fish.
What do my Hake F307 IgE results mean?
Low Hake F307 IgE
A low or undetectable result makes IgE-mediated hake allergy less likely, but it does not fully rule it out. Timing matters: if your reaction was very convincing, your clinician may still consider skin testing, testing for other fish, or a supervised food challenge. Non-IgE reactions, food poisoning, or reactions to additives or cross-contact can also mimic allergy symptoms.
In-range / negative Hake F307 IgE
Many labs report this test as negative vs. positive rather than “optimal.” If your result is in the lab’s negative range and you have never reacted to hake, it generally supports that you are unlikely to have an IgE-mediated hake allergy. If you have symptoms, your clinician will usually re-check the story: what you ate, how it was prepared, and whether another seafood item is a better suspect.
High Hake F307 IgE
A higher result suggests stronger sensitization and increases the probability of an IgE-mediated reaction, especially if your symptoms occurred soon after eating hake. However, the number alone does not predict severity, and it cannot tell you whether a future reaction will be mild or life-threatening. Your clinician may recommend strict avoidance, evaluation for other fish allergies, and an emergency plan if your history suggests risk.
Factors that influence Hake F307 IgE
Your overall allergic tendency (atopy), including eczema, asthma, or multiple allergies, can be associated with higher IgE results. Recent exposure does not usually “spike” specific IgE immediately, but IgE levels can change over months to years, especially in children. Cross-reactivity to other fish species can contribute to a positive result even if you have not knowingly eaten hake. Medications like antihistamines do not typically affect blood IgE results, but they can change symptoms, which affects how the test is interpreted.
What’s included
- Hake (F307) Ige
Frequently Asked Questions
Do I need to fast for a Hake F307 IgE blood test?
Fasting is not usually required for allergen-specific IgE testing. If you are bundling this with other labs that do require fasting, follow the instructions for the full order.
What does “F307” mean on my lab report?
F307 is a lab coding convention used by many allergy testing platforms to identify the specific allergen (hake). It helps standardize ordering and reporting across laboratories.
If my Hake IgE is positive, does that mean I will have anaphylaxis?
No. A positive result indicates sensitization, which increases the chance of an allergic reaction, but it does not predict reaction severity. Your past reactions, asthma status, and exposure circumstances are key parts of risk assessment.
Can I be allergic to hake but not other fish?
Yes. Some people react to multiple fish species due to shared proteins, while others react to only certain fish. If you are trying to understand which fish are safe for you, your clinician may recommend a broader fish IgE panel and, in some cases, supervised food challenges.
How is this different from a skin prick test?
A blood specific IgE test measures IgE antibodies in your serum, while a skin prick test measures an immediate skin response to an allergen extract. Either can be useful, and discordant results happen, so clinicians often choose based on your history, medication use, and access to allergy care.
When should I retest Hake F307 IgE?
Retesting is usually considered when it would change decisions, such as reassessing an allergy over time or before considering a supervised food challenge. Many clinicians wait months to a year or longer, because IgE trends typically change gradually rather than week to week.