Energy Fatigue Quick Check Panel
This blood test panel checks thyroid, iron status, anemia clues, inflammation, and key nutrients to help explain fatigue and guide next steps.
This panel bundles multiple biomarker tests in one order—your report explains how results fit together.
Fatigue is rarely explained by one number. This lab panel bundles several high-yield blood tests into a single draw so you can look for common, fixable patterns—like low iron stores, subtle thyroid issues, anemia clues, inflammation, or nutrient gaps—before you spend months guessing.
Your results are most useful when you read them together. A “normal” value in one area (like TSH) does not automatically rule out other contributors, and a borderline result can matter more when it matches your symptoms and the rest of the panel.
Do I need this panel?
This panel can be a good fit if you feel persistently tired, run down, or “not yourself” for weeks to months—especially when sleep, stress, and workload do not fully explain it. It is also useful if you are trying to rule out common medical contributors to low energy before you make big changes to supplements, diet, or training.
You may want this panel if you have any of these patterns: fatigue with brain fog, reduced exercise tolerance, shortness of breath on exertion, frequent headaches, cold intolerance, hair shedding, heavier periods, restless legs, or a history of low iron or thyroid concerns. Post-viral fatigue and busy schedules can make symptoms feel nonspecific; a targeted panel helps you avoid ordering random single tests that do not connect into a clear story.
This panel is not designed to diagnose a condition on its own. It gives you a structured starting point for clinician-directed care—helping you and your clinician decide whether to address nutrition, investigate blood loss, evaluate thyroid function more deeply, or expand testing when symptoms are multi-system or persistent.
This panel combines standard blood tests commonly run on automated analyzers; reference ranges and optimal targets can vary by lab, age, sex, pregnancy status, and clinical context.
Lab testing
Order labs to measure Energy & Fatigue Quick Check
from $40.22 at Quest Diagnostics
About 1 week
Schedule online — results typically within a week
Clear next steps
Guidance included, with follow-up care available
HSA / FSA
Eligible for pre-tax health spending accounts
Get this panel with Vitals Vault
Vitals Vault lets you order this fatigue-focused lab panel without turning your symptoms into a months-long referral process. You get a bundled set of tests that are meant to be interpreted together, not as isolated flags.
After your results post, you can use PocketMD to review the pattern across thyroid, iron status, anemia clues, inflammation, and nutrients. That context matters: the same ferritin value can mean different things depending on CRP (inflammation), hemoglobin and red blood cell indices, and your symptoms.
If this quick check shows a clear direction, you can act efficiently—adjusting nutrition or supplements with guidance, discussing medication changes, or planning a targeted follow-up. If results are mixed or symptoms are broader (brain fog, dizziness, palpitations, GI issues, or post-viral crashes), PocketMD can help you decide whether to repeat this panel, add a more comprehensive fatigue panel, or pivot to a different workup.
- One blood draw that screens multiple common fatigue drivers
- Designed for pattern recognition (not a single “answer” lab)
- PocketMD support to translate results into next-step questions for your clinician
- Easy re-testing to track whether a change is working
Key benefits of the Energy Fatigue Quick Check panel
- Screens for iron depletion and iron-deficiency patterns that can cause fatigue even before anemia is obvious.
- Checks thyroid signaling and thyroid hormone availability so “normal TSH but I’m tired” can be interpreted in context.
- Uses a complete blood count to spot anemia clues, red blood cell size patterns, and other hematology signals tied to low energy.
- Adds inflammation context so you can tell when ferritin or other markers may be shifted by an inflammatory state.
- Identifies common nutrient gaps (like B12 or vitamin D) that can overlap with fatigue, low mood, or reduced performance.
- Helps you avoid panel shopping by bundling high-yield tests that often guide the first round of fatigue evaluation.
- Creates a baseline you can trend after treatment changes (iron repletion, thyroid dose adjustments, nutrition, or recovery planning).
What is the Energy Fatigue Quick Check panel?
The Energy Fatigue Quick Check is a bundled blood test panel designed to look for several of the most common, fixable lab patterns associated with ongoing fatigue. Instead of ordering one test at a time, this panel groups complementary markers so you can interpret your results as a differential—multiple possible contributors that can be confirmed, ruled out, or prioritized.
Most fatigue workups start with a few categories:
• Oxygen-carrying capacity and red blood cell production (anemia and related patterns) • Iron status (iron stores, transport, and utilization) • Thyroid function (signals from the pituitary and circulating thyroid hormone) • Inflammation (which can shift iron markers and correlate with systemic symptoms) • Nutrient status (common deficiencies that can mimic or worsen fatigue)
This panel is meant to be a “quick check,” not the final word. If your symptoms are severe, progressive, or accompanied by red flags (chest pain, fainting, black/tarry stools, unexplained weight loss, persistent fever, or new neurologic symptoms), you should seek urgent medical evaluation rather than relying on a screening panel.
What do my panel results mean?
When key parts of the panel are low
A “low pattern” in this panel often means your energy systems may be under-supplied. Common examples include low ferritin (low iron stores), low serum iron and/or low transferrin saturation, low hemoglobin or hematocrit, or low vitamin B12 or vitamin D. When these show up together—such as low ferritin plus small red blood cells (low MCV) or a rising RDW—it can point toward iron deficiency as a contributor to fatigue. Low-normal thyroid hormones with symptoms can also matter, especially if TSH is not clearly elevated but free T4 is toward the lower end. The next step is usually to confirm the pattern, look for a cause (dietary intake, absorption issues, menstrual blood loss, GI blood loss), and re-test after a defined intervention window.
When the panel looks optimal overall
If thyroid markers, iron studies, blood counts, inflammation markers, and key nutrients are all in a healthy range, that is still useful information: it makes common fixable lab causes less likely. In that situation, fatigue is more likely to be driven by sleep quality, circadian disruption, overtraining/under-recovery, medication effects, mood or stress physiology, post-viral dysautonomia patterns, or less common medical issues that require a different set of tests. “Optimal” does not mean your symptoms are not real—it means this particular panel did not reveal a clear deficiency or inflammatory signal. PocketMD can help you decide whether to broaden testing (for example, metabolic, hormonal, or inflammatory expansion) or focus on non-lab drivers with a structured plan.
When key parts of the panel are high
A “high pattern” can mean different things depending on which markers are elevated. Elevated CRP (C-reactive protein) suggests inflammation and can make ferritin look higher than your true iron stores, which is why iron markers should be read together. High TSH can suggest hypothyroidism, especially if free T4 is low or low-normal and symptoms match; however, mild elevations can be transient or medication-related. High ferritin may reflect inflammation, liver stress, alcohol intake, metabolic issues, or iron overload in some cases—context from CRP, transferrin saturation, and your history matters. Abnormal blood count patterns (like high hemoglobin/hematocrit) can relate to dehydration, altitude, smoking, sleep apnea, or other causes and should be discussed with a clinician.
Factors that influence fatigue-related labs
Many real-world factors can shift this panel without representing a single diagnosis. Recent infection, chronic inflammatory conditions, intense training, and poor sleep can raise CRP and change iron handling. Menstrual bleeding, pregnancy/postpartum status, blood donation, and GI conditions can lower iron stores. Thyroid labs can be influenced by pregnancy, acute illness, iodine intake, and medications (for example, biotin supplements can interfere with some immunoassays; thyroid hormone, steroids, and certain psychiatric or cardiac medications can also affect results). Supplements can also change interpretation—iron, B12, and vitamin D taken shortly before testing may improve numbers without addressing the root cause. For the clearest interpretation, bring your symptom timeline, medication/supplement list, and any recent illness or major training changes into the conversation.
What’s included in this panel
- Vitamin D, 25-Hydroxy
- Vitamin B12
- Ferritin
- TSH
Similar tests and next-step panels
Frequently Asked Questions
Do I need to fast for this panel?
Fasting is not always required for the core components of this panel, but fasting status can affect some lab values and how consistent your trends are over time. If you can, a morning draw with an overnight fast (8–12 hours) and good hydration can make results easier to compare. If you are prone to lightheadedness or have medical reasons not to fast, prioritize safety and follow your clinician’s guidance.
Why not just order TSH if I’m tired?
TSH is a useful screening test, but fatigue is often multi-factorial. You can have fatigue with a normal TSH due to low iron stores, anemia patterns, inflammation, or nutrient gaps. This panel is designed to reduce “single-test tunnel vision” by checking several common contributors at once.
How do I interpret ferritin if my CRP is high?
Ferritin is both an iron-storage marker and an acute-phase reactant, meaning it can rise with inflammation. If CRP is elevated, ferritin may look normal or high even when usable iron is limited. In that case, transferrin saturation, serum iron, TIBC, and CBC indices become especially important for interpreting whether iron deficiency is still possible.
Can this panel explain post-viral fatigue or long recovery after illness?
It can identify common, treatable issues that often coexist with post-viral fatigue—like iron depletion, thyroid shifts, inflammation signals, or nutrient deficiencies. However, post-viral fatigue can also involve autonomic dysfunction, sleep disruption, and exertion intolerance that may not show up on basic labs. If your symptoms are persistent or multi-system, you may need a broader evaluation beyond this quick check.
Should I stop supplements before testing?
Do not stop prescribed medications unless your clinician tells you to. For supplements, it helps to be consistent: if you recently started iron, B12, or vitamin D, your numbers may improve before the underlying cause is addressed. Some assays can be affected by high-dose biotin; if you take biotin, ask your clinician whether you should pause it for a short period before thyroid testing. Always bring a complete supplement list when reviewing results.
How soon should I re-test if I start iron or vitamin supplements?
Timing depends on what was abnormal and what you changed. Many clinicians re-check iron studies and CBC after several weeks to a few months, while vitamin D is often re-checked after a similar interval depending on dose and baseline level. Re-testing too early can be misleading; re-testing too late can delay course correction. PocketMD can help you think through a reasonable follow-up window to discuss with your clinician.
Is this panel enough to evaluate anemia?
This panel includes a CBC and iron studies that cover many common anemia patterns, especially iron deficiency. If anemia is present or suspected, additional tests may be needed based on your pattern and history (for example, folate, reticulocyte count, hemolysis markers, kidney function, or evaluation for blood loss).