Allergen Specific IgG Lime (Food Sensitivity) Biomarker Testing
It measures IgG antibodies to lime proteins to support food-sensitivity discussions, with convenient ordering and clear results through Vitals Vault/Quest.
With Vitals Vault, you have access to a comprehensive range of biomarker tests.
This test looks for IgG antibodies your immune system has made against lime proteins. It is often marketed as a “food sensitivity” marker, which is different from classic, immediate food allergy testing.
If you are trying to connect symptoms like bloating, irregular stools, headaches, skin flares, or “brain fog” to specific foods, an IgG result can be one piece of information to review with your clinician. It is not a stand-alone diagnosis, and it does not prove that lime is the cause of your symptoms.
The most useful way to use a lime-specific IgG result is as a starting point for a structured plan: clarify your symptoms and timing, consider other causes, and decide whether a short, clinician-guided elimination and re-challenge makes sense.
Do I need a Allergen Specific IgG Lime test?
You might consider a lime-specific IgG test if you notice symptoms that seem to track with citrus-containing foods or drinks, but the pattern is inconsistent or delayed. IgG-related reactions, when they occur, are often described as hours to days after exposure rather than minutes.
This test can also be reasonable if you have already addressed more common contributors to digestive symptoms (such as lactose intolerance, celiac screening when appropriate, medication side effects, or inadequate fiber) and you and your clinician want additional data to guide a time-limited elimination trial.
You generally do not need this test for suspected immediate allergy symptoms such as hives, lip or tongue swelling, wheezing, or anaphylaxis after lime exposure. Those scenarios call for allergy-focused evaluation, typically with IgE testing and/or specialist assessment.
If you are pregnant, immunocompromised, or managing complex GI disease (like inflammatory bowel disease), it is especially important to interpret any IgG result in context. Testing should support clinician-directed care and symptom tracking, not self-diagnosis.
This is a laboratory-developed test performed in a CLIA-certified lab; results are intended for clinical correlation and are not diagnostic on their own.
Lab testing
Order lime-specific IgG testing and view results in your Vitals Vault dashboard.
Schedule online, results typically within about a week
Clear reporting and optional clinician context
HSA/FSA eligible where applicable
Get this test with Vitals Vault
Vitals Vault lets you order lime-specific IgG testing without a separate doctor visit, and you can complete your blood draw through a national lab network.
After your result posts, PocketMD can help you translate the number into plain language: what “low,” “in range,” or “high” typically means for this type of antibody test, what follow-up questions to ask, and how to plan a careful elimination and reintroduction if you choose to test your symptoms.
If your symptoms are broader than one food, you can use Vitals Vault to expand to related markers or panels so you are not making decisions from a single data point. Many people get the most value by trending symptoms and retesting only when it would change the plan (for example, after a sustained dietary change).
- Order online and schedule a local blood draw
- PocketMD guidance for next steps and questions to ask
- Easy re-ordering if you and your clinician decide to retest
Key benefits of Allergen Specific IgG Lime testing
- Gives you a measurable data point about immune recognition of lime proteins (IgG antibodies).
- Helps prioritize which foods to trial in a structured elimination and re-challenge plan.
- Can add context when symptoms are delayed and do not fit an immediate IgE-type allergy pattern.
- Supports more focused conversations with your clinician about whether lime is likely relevant for you.
- May help you avoid overly broad dietary restriction by narrowing attention to specific candidates.
- Provides a baseline you can compare against later if your diet or symptoms change meaningfully.
- Pairs well with complementary testing (like IgE or broader food panels) when your history suggests multiple mechanisms.
What is Allergen Specific IgG Lime?
Allergen specific IgG is a blood test that measures IgG antibodies directed at a particular substance—in this case, proteins from lime. IgG is one of the antibody classes your immune system uses to recognize exposures you have had, including foods.
A key point is that IgG “positivity” does not automatically mean you are allergic to lime or that lime is harmful for you. Many people develop IgG antibodies to foods they eat regularly, and in some contexts IgG can reflect exposure or even immune tolerance rather than disease.
Because symptoms attributed to “food sensitivities” are often non-specific and can overlap with many other conditions, clinicians typically use IgG results as supportive information. The result is most meaningful when it matches your history (what you ate, the timing, and reproducible symptoms) and when you test the hypothesis with a careful, time-limited dietary trial.
IgG vs IgE: why the distinction matters
IgE antibodies are the classic marker for immediate-type allergy, where symptoms can start within minutes to a couple of hours (hives, swelling, wheeze, vomiting). IgG antibodies are not the standard tool for diagnosing immediate allergy. If you have rapid, reproducible reactions to lime, IgE-focused evaluation is usually the safer and more appropriate path.
What “lime” means on the lab report
The assay uses lime-derived antigen to detect whether your blood contains IgG antibodies that bind to it. Different labs may report results in different units or classes, so interpretation should follow the reference information on your specific report rather than a single universal cutoff.
What do my Allergen Specific IgG Lime results mean?
Low lime-specific IgG
A low result generally means the lab did not detect meaningful IgG binding to lime proteins, or it was below the lab’s reporting threshold. This makes lime a less likely candidate to prioritize for an elimination trial, especially if your symptoms are vague or inconsistent. It does not rule out non-immune intolerance (like acid irritation) or an immediate IgE-type allergy, which is evaluated differently.
In-range (negative) or borderline lime-specific IgG
An in-range or borderline result is often interpreted similarly to low: there is no strong signal that your immune system is producing elevated IgG to lime. If you still strongly suspect lime based on a clear symptom pattern, your clinician may recommend a short, structured elimination and reintroduction rather than additional antibody testing. In many cases, the “best” result is the one that prevents unnecessary restriction.
High lime-specific IgG
A high result means your blood shows increased IgG antibody binding to lime proteins compared with the lab’s reference threshold. This can happen because you eat lime or citrus frequently, because your immune system has recognized it in the past, or because it is associated with symptoms in some people. The result is not proof of a harmful reaction by itself, so the next step is usually correlation: do your symptoms reliably improve with a time-limited elimination and return with re-challenge?
Factors that influence lime-specific IgG results
Recent and frequent exposure to lime (or foods containing lime) can increase the chance of a higher IgG result because IgG often tracks exposure. Immune-modifying medications or conditions that affect antibody production can shift results in either direction. Cross-reactivity is also possible: proteins in related citrus fruits may share features that affect binding in some assays, so your clinician may look at your broader diet and other citrus reactions when interpreting the number.
What’s included
- Lime Igg*
Frequently Asked Questions
Is lime-specific IgG the same as a lime allergy test?
No. IgG testing is not the standard test for immediate-type food allergy. If you have rapid symptoms like hives, swelling, wheezing, or vomiting soon after lime exposure, ask your clinician about IgE testing and allergy-focused evaluation.
Do I need to fast for an allergen-specific IgG test?
Fasting is usually not required for IgG antibody testing. If you are combining this with other labs that do require fasting (like lipids or glucose/insulin), follow the instructions for the full set of tests you ordered.
What does a high IgG to lime actually mean?
It means the assay detected more IgG antibody binding to lime proteins than the lab’s threshold. That can reflect exposure and immune recognition, and it may or may not relate to symptoms. The most practical next step is to compare the result to your history and consider a structured elimination and re-challenge with clinician guidance.
Can I have symptoms from lime if my IgG is low or negative?
Yes. Symptoms can come from non-immune mechanisms (like acidity, reflux triggers, or food additives in lime-containing products), and immediate allergy is evaluated with IgE rather than IgG. A low IgG result simply makes an IgG-associated sensitivity less likely to be a useful explanation.
When should I retest lime-specific IgG?
Retesting is most useful when it would change your plan—for example, after you have made a sustained dietary change and you want to see whether the marker trends down over time. Many clinicians wait at least 8–12 weeks after a consistent change before repeating antibody-type tests, but timing should be individualized.
Should I eliminate lime if my IgG is high?
Not automatically. A high IgG result is a signal to interpret, not a diagnosis. If you and your clinician decide to trial elimination, keep it time-limited, track symptoms, and plan a reintroduction step so you can test whether lime is truly a trigger.