Advanced Lipid Panel Cardio IQ (advanced cholesterol testing)
It measures cholesterol particles and related risk markers beyond a standard lipid panel, with convenient ordering and Quest-based testing through Vitals Vault.
This panel bundles multiple biomarker tests in one order—your report explains how results fit together.
A standard cholesterol test tells you how much cholesterol is riding in your blood. An Advanced Lipid Panel Cardio IQ goes a step further by looking at the number and type of lipoprotein particles that carry cholesterol and triglycerides.
That extra detail can matter because two people can have the same LDL-C (“bad cholesterol”) but very different LDL particle counts, particle sizes, and inherited risk markers like lipoprotein(a). Those differences can change how you and your clinician think about prevention and follow-up.
This test does not diagnose heart disease by itself. It gives you a clearer picture of lipid-related risk so you can pair it with your personal history, blood pressure, glucose/insulin markers, and (when appropriate) imaging.
Do I need an Advanced Lipid Panel Cardio IQ test?
You might consider an advanced lipid panel if your standard lipid panel does not match your real-world risk. For example, you may have “normal” LDL-C but a strong family history of early heart disease, metabolic syndrome, or a prior abnormal coronary calcium score.
It can also be useful when your triglycerides are elevated, your HDL-C is low, or you have insulin resistance, because these patterns often come with a higher number of smaller, denser LDL particles even when LDL-C looks acceptable.
If you are already working on cholesterol lowering—through lifestyle changes or medication—advanced markers like ApoB or LDL particle number can help you and your clinician judge whether the therapy is reducing the particles most linked to plaque formation.
If you are pregnant, acutely ill, or recently had major weight loss, your lipids can shift temporarily. In those cases, it may make sense to time testing with your clinician so the result reflects your usual baseline.
This panel is performed in a CLIA-certified laboratory; results should be interpreted with your clinician and are not a standalone diagnosis of cardiovascular disease.
Lab testing
Order labs to measure Advanced Lipid Panel, Cardio IQ
from $100.99 at Quest Diagnostics
About 1 week
Schedule online — results typically within a week
Clear next steps
Guidance included, with follow-up care available
HSA / FSA
Eligible for pre-tax health spending accounts
Get this test with Vitals Vault
Vitals Vault lets you order an Advanced Lipid Panel Cardio IQ without needing a separate referral visit, and you can choose a convenient local draw location.
Once your results are in, PocketMD can help you translate the report into plain language: what each marker measures, which results deserve follow-up, and what companion labs are commonly used to confirm patterns (such as A1c, fasting insulin, or hs-CRP).
If you are tracking progress, you can re-order the same panel to compare trends over time, which is often more useful than reacting to a single number. Your clinician can then use those trends alongside your overall risk profile to guide next steps.
- Order online and complete your blood draw at a participating lab location
- PocketMD support for next-step questions and retest planning
- Designed for trend tracking, not one-off guesswork
Key benefits of Advanced Lipid Panel Cardio IQ testing
- Shows LDL particle burden (often via LDL-P) when LDL-C alone may underestimate risk.
- Adds ApoB, a direct count of atherogenic particles, which can clarify treatment targets.
- Identifies inherited risk markers like lipoprotein(a) that are not on standard lipid panels.
- Characterizes LDL size and pattern (A vs B) to flag small, dense LDL tendencies.
- Helps explain “discordance” when your cholesterol numbers look fine but risk factors are present.
- Supports therapy monitoring by tracking particle-focused markers after lifestyle or medication changes.
- Makes it easier to plan follow-up testing and questions using PocketMD and repeatable ordering through Vitals Vault.
What is Advanced Lipid Panel Cardio IQ?
An Advanced Lipid Panel Cardio IQ is a blood test that expands on the standard lipid panel. Instead of focusing only on cholesterol concentration (like LDL-C and HDL-C), it measures additional markers that reflect how many cholesterol-carrying particles you have and what kind they are.
Cholesterol travels through your bloodstream inside lipoproteins. The particles most associated with plaque formation are “atherogenic” particles, which include LDL and other ApoB-containing particles. In many people, the number of these particles (often reflected by ApoB or LDL particle number) tracks cardiovascular risk more closely than LDL-C alone.
The panel may also include lipoprotein(a), an inherited LDL-like particle that can raise risk even when other lipid numbers are favorable. Because Lp(a) is largely genetic, it is often checked at least once in adulthood, and then rechecked selectively based on clinical context.
You can think of this test as answering two questions at the same time: how much cholesterol is being carried, and how many “vehicles” are carrying it.
How it differs from a standard lipid panel
A standard lipid panel reports total cholesterol, LDL-C, HDL-C, and triglycerides (sometimes with calculated non-HDL-C). An advanced panel adds particle-based metrics (like LDL-P), apolipoproteins (like ApoB and sometimes ApoA1), and inherited markers (like Lp(a)). These additions can be especially helpful when triglycerides are high, when LDL-C is borderline, or when you are deciding how aggressive prevention should be.
Why particle number matters
LDL-C is the amount of cholesterol inside LDL particles, not the number of particles. If each particle carries less cholesterol (a common pattern with insulin resistance), you can have a normal LDL-C but a high particle count. More particles means more opportunities for particles to enter the artery wall and contribute to plaque over time.
What do my Advanced Lipid Panel Cardio IQ results mean?
Low (lower-risk) patterns on an advanced lipid panel
In this context, “low” usually means lower levels of atherogenic particle markers, such as a lower ApoB and/or a lower LDL particle number, along with favorable triglycerides and non-HDL-C. This pattern generally suggests fewer cholesterol-carrying particles that can contribute to plaque formation. If your Lp(a) is low and your inflammatory markers (if checked) are also favorable, your lipid-related risk picture is often simpler. Even with good numbers, your clinician may still consider family history, blood pressure, smoking status, and diabetes risk.
Optimal results (what you are usually aiming for)
Optimal results typically show alignment between LDL-C and particle-based markers, meaning the cholesterol concentration and particle burden tell the same story. Triglycerides are usually in a healthy range, HDL-C is not suppressed, and LDL size/pattern does not strongly suggest small, dense LDL predominance. Many clinicians also look for ApoB and non-HDL-C to be consistent with your overall risk category rather than chasing a single universal target. If you are on therapy, “optimal” can also mean your numbers are improving in the right direction and staying stable on repeat testing.
High (higher-risk) patterns on an advanced lipid panel
Higher ApoB and/or higher LDL particle number generally indicate a higher burden of atherogenic particles. If your LDL-C is only mildly elevated but ApoB or LDL-P is high, that discordance can signal hidden risk, often seen with insulin resistance or higher triglycerides. A high Lp(a) suggests inherited risk that may warrant earlier or more intensive prevention discussions, especially if you also have a family history of early cardiovascular events. Your clinician may pair these results with other data—such as A1c, blood pressure, hs-CRP, or imaging—to decide what to do next.
Factors that influence advanced lipid markers
Recent illness, major stress, pregnancy, and rapid weight loss can temporarily shift cholesterol and triglycerides, which can affect particle measurements. Diet changes, alcohol intake, and exercise patterns can move triglycerides and HDL-C within weeks, while LDL-related markers may take longer to stabilize. Medications (including statins, ezetimibe, PCSK9 inhibitors, hormone therapy, and some acne or HIV medications) can significantly change LDL-C, ApoB, and particle counts. Genetics strongly influence Lp(a), so lifestyle changes may have limited impact on that specific marker even when other lipids improve.
What’s included
- Apolipoprotein B
- Chol/Hdlc Ratio
- Cholesterol, Total
- Hdl Cholesterol
- Hdl Large
- Ldl-Cholesterol
- Ldl Medium
- Ldl Particle Number
- Ldl Pattern
- Ldl Peak Size
- Ldl Small
- Lipoprotein (A)
- Non Hdl Cholesterol
- Triglycerides
Similar and related tests
Frequently Asked Questions
Do I need to fast for an Advanced Lipid Panel Cardio IQ?
Many clinicians prefer a fasting sample (often 9–12 hours) because triglycerides can rise after eating and can influence calculated values and particle patterns. Some components may still be interpretable non-fasting, but if you are comparing results over time, use the same fasting status each time. Follow the collection instructions on your order or your clinician’s guidance.
What is the difference between LDL-C and LDL particle number (LDL-P)?
LDL-C is the amount of cholesterol inside LDL particles, while LDL-P estimates how many LDL particles are circulating. You can have normal LDL-C but high LDL-P if each particle carries less cholesterol, which is common with insulin resistance and higher triglycerides. LDL-P (and ApoB) can better reflect the number of atherogenic particles that may contribute to plaque.
Is ApoB more important than LDL cholesterol?
ApoB is a protein found on atherogenic particles (including LDL), so it acts like a particle count. In many people, ApoB tracks cardiovascular risk well, especially when LDL-C and triglycerides are discordant. It is not “more important” in every situation, but it can be a clearer target when you are trying to reduce particle burden.
What does a high lipoprotein(a) mean, and can I lower it?
A high Lp(a) usually reflects inherited risk, and levels are relatively stable across your life. Lifestyle changes that improve LDL-C and triglycerides may not significantly lower Lp(a), but they can still reduce overall risk. Your clinician may focus on lowering ApoB/LDL-related markers more aggressively and may consider additional risk assessment based on your history.
How often should I repeat an advanced lipid panel?
A common approach is to retest about 8–12 weeks after a meaningful change, such as starting or adjusting lipid-lowering medication or making sustained diet and exercise changes. If you are stable and monitoring long-term risk, your clinician may repeat it less often (for example, annually). The best interval depends on your baseline risk and whether you are actively changing treatment.
Can this panel tell me if I already have blocked arteries?
No. This panel estimates lipid-related risk and helps guide prevention, but it does not diagnose plaque or blockages. If your results suggest higher risk, your clinician may consider imaging or other tests (such as coronary artery calcium scoring) to assess plaque burden directly.
Why are my LDL-C and ApoB telling different stories?
This is called lipid “discordance.” It can happen when LDL particles are smaller and carry less cholesterol, so LDL-C looks acceptable while ApoB (particle count) is higher. Triglycerides, insulin resistance, and genetics can contribute, which is why pairing this panel with glucose/insulin markers and your clinical history is often helpful.