---
title: "Systemic Immune-Inflammation Index (SII): Calculation"
description: "SII estimates immune-inflammation using CBC cell counts to flag higher inflammatory stress; order labs and review trends with Vitals Vault/Quest."
canonical: "https://www.vitalsvault.com/biomarkers/systemic-immune-inflammation-index-sii"
last-updated: 2026-08-22
---

# Systemic Immune-Inflammation Index (SII): Calculation

> SII estimates immune-inflammation using CBC cell counts to flag higher inflammatory stress; order labs and review trends with Vitals Vault/Quest.

---

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