IGF-1 levels reflect overall growth hormone activity and are more stable than GH levels (which fluctuate throughout the day). It's used to diagnose growth hormone deficiency or excess (acromegaly/gigantism) and monitor GH replacement therapy.
IGF-1 levels reflect overall growth hormone activity and are more stable than GH levels (which fluctuate throughout the day). It's used to diagnose growth hormone deficiency or excess (acromegaly/gigantism) and monitor GH replacement therapy.
Insulin-like Growth Factor 1 (IGF-1) is a hormone primarily produced by the liver in response to growth hormone (GH) stimulation. It mediates many of the growth-promoting effects of GH.
Reference ranges may vary slightly between laboratories. The values below represent commonly accepted clinical ranges.
Ranges shown are general guidelines. Consult your provider for personalized interpretation.
| Biomarker | Reference range | Interpretation |
|---|---|---|
Igf 1, Lc/Ms (Male — Optimal) | 115–307 ng/mL | Target range for optimal health |
Igf 1, Lc/Ms (Female — Optimal) | 101–267 ng/mL | Target range for optimal health |
Igf 1, Lc/Ms (Male — Standard) | 53–331 ng/mL | Standard lab reference range |
Igf 1, Lc/Ms (Female — Standard) | 47–289 ng/mL | Standard lab reference range |
High Igf 1, Lc/Ms levels above the standard range may indicate an underlying health condition that warrants further evaluation.
Low Igf 1, Lc/Ms levels below the standard range may indicate an underlying health condition that warrants further evaluation.
Insulin-like Growth Factor 1 (IGF-1) is a hormone primarily produced by the liver in response to growth hormone (GH) stimulation. It mediates many of the growth-promoting effects of GH.
Optimal range men: 115–307 ng/mL; women: 101–267 ng/mL. Standard range men: 53–331 ng/mL; women: 47–289 ng/mL. Always interpret ranges in clinical context, not as a stand-alone diagnosis.
IGF-1 levels reflect overall growth hormone activity and are more stable than GH levels (which fluctuate throughout the day). It's used to diagnose growth hormone deficiency or excess (acromegaly/gigantism) and monitor GH replacement therapy.
Low IGF-1: In children - growth failure, short stature. In adults - decreased muscle mass, increased body fat, fatigue, reduced bone density, poor exercise tolerance. High IGF-1: Features of acromegaly - enlarged hands/feet, facial changes, joint pain.
Low IGF-1: Growth hormone deficiency, malnutrition, liver disease, poorly controlled diabetes, hypothyroidism, chronic illness, aging. High IGF-1: Acromegaly (GH excess), gigantism, puberty, pregnancy, obesity.
Igf 1, Lc/Ms can be ordered through Vitals Vault without a doctor referral, then completed at CLIA-certified Quest Diagnostics locations nationwide. After checkout, you receive clear draw instructions, digital requisition details, and a structured report that explains whether your result is in standard range, optimal range, or needs follow-up review.
Start by identifying the root cause, then use targeted nutrition, training, sleep, stress, and follow-up retesting to verify improvement. Igf 1, Lc/Ms should be optimized with a personalized plan, not guesswork.
You should speak with a clinician if Igf 1, Lc/Ms is significantly outside the reference range, trending in the wrong direction across repeat tests, or accompanied by symptoms like fatigue, chest discomfort, dizziness, weight change, or persistent inflammation signs. Immediate medical care is important for severe symptoms, not just abnormal numbers in isolation.
A practical retesting cadence for Igf 1, Lc/Ms is every 8 to 12 weeks after major lifestyle, nutrition, or medication changes, and every 3 to 6 months for stable long-term tracking. Faster cadence is useful when values are clearly abnormal, while maintenance cadence helps confirm durability once results stabilize.
You can compare Essential ($99), Advanced ($199), and Max ($399) plans during checkout to confirm Igf 1, Lc/Ms inclusion before purchasing. If Igf 1, Lc/Ms is not in your selected tier, you can upgrade plans or add targeted testing so your panel matches your goals, symptoms, and retesting strategy.
Igf 1, Lc/Ms is included in our comprehensive biomarker panels, processed at CLIA-certified Quest Diagnostics locations nationwide.
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Medical Disclaimer: This content is for educational and informational purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with any questions about a medical condition or treatment. Do not disregard professional medical advice or delay seeking it because of information presented here.