Heart Health 3 Essential Blood Test Panel
This heart health blood test panel bundles key lipid and inflammation markers so you can spot risk patterns, track treatment response, and plan next steps.
This panel bundles multiple biomarker tests in one order—your report explains how results fit together.
This is a lab panel, meaning you get multiple cardiovascular-related blood tests in one draw. It is designed as a starter snapshot: the numbers are most useful when you read them together (not one at a time) and compare them to your personal risk factors, medications, and trends over time.
Do I need this panel?
You might consider the Heart Health 3 Essential Blood Test Panel if you want a clear baseline for cardiovascular risk, especially if you have a family history of early heart attack or stroke, high blood pressure, prediabetes/diabetes, excess abdominal weight, or you are trying to improve diet, exercise, sleep, or alcohol habits and want objective feedback.
This panel is also useful if you are already on heart-related medications (such as a statin, ezetimibe, or triglyceride-lowering therapy) and you want to see whether your overall risk pattern is moving in the right direction—not just whether one cholesterol number changed.
You may want to prioritize testing sooner if you have been told you have “high cholesterol,” you have confusing lipid jargon in past results (LDL, non-HDL, ApoB), or you have an unexpected result like high triglycerides or low HDL. A single value rarely tells the whole story; patterns across the panel can point to insulin resistance, inflammation, or medication effects.
This panel supports clinician-directed care and shared decision-making. It does not diagnose heart disease by itself, but it can help you and your clinician decide what to address first and what follow-up testing makes sense.
Results and reference ranges can vary by lab method; interpret your panel in context of your age, sex, medical history, medications, and whether the sample was fasting.
Lab testing
Order labs to measure Heart Health Plus Panel
from $223.47 at Quest Diagnostics
About 1 week
Schedule online — results typically within a week
Clear next steps
Guidance included, with follow-up care available
HSA / FSA
Eligible for pre-tax health spending accounts
Get this panel with Vitals Vault
Vitals Vault makes it straightforward to order a heart health lab panel and get a clean, organized view of your results. You can use this panel as a baseline, as a check-in after lifestyle changes, or as a way to monitor how well a treatment plan is working.
After your blood draw, you can review results in one place and focus on the relationships between markers—like whether a high LDL-C is paired with high ApoB, whether triglycerides suggest insulin resistance, or whether inflammation may be influencing your overall risk picture.
If you want help making sense of multiple results at once, PocketMD can walk you through what each marker means, what patterns commonly suggest, and what questions to bring to your next appointment. If your results suggest you need deeper cardiovascular risk clarification, you can also consider expanding to a more advanced lipid-focused panel.
- Designed for pattern-based interpretation across multiple cardiovascular markers
- Useful for baseline testing and for tracking changes over time
- PocketMD support to help you turn results into next-step questions
Key benefits of the Heart Health 3 Essential Blood Test Panel
- Gives you a starter cardiovascular risk snapshot by combining core lipid markers with an inflammation signal.
- Helps you look beyond “total cholesterol” by separating LDL-related risk, HDL, and triglyceride patterns.
- Supports medication monitoring by showing whether lipid changes are consistent across related markers.
- Flags common metabolic patterns (like insulin resistance–associated high triglycerides and low HDL) that can change your risk strategy.
- Adds context when your LDL-C is borderline by pairing it with particle-related risk (ApoB) and systemic inflammation (hs-CRP).
- Creates a baseline you can trend after diet, weight loss, exercise, alcohol changes, or starting/stopping medications.
- Helps you decide when it is worth upgrading to advanced lipid testing (such as Lp(a) and particle measures) based on your pattern and family history.
What is the Heart Health 3 Essential Blood Test Panel?
The Heart Health 3 Essential Blood Test Panel is a bundled lab panel that measures several blood markers commonly used to estimate cardiovascular risk and to monitor how your risk profile changes over time. Instead of focusing on a single number, this panel is meant to be read as a set.
Most people recognize “cholesterol” as one thing, but cardiovascular risk is more nuanced. Lipids include LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), and triglycerides. These values help estimate how much cholesterol is being carried in different lipoprotein particles and how your metabolism is handling fats and carbohydrates.
This panel also includes apolipoprotein B (ApoB), which reflects the number of atherogenic (plaque-forming) particles in circulation. Two people can have the same LDL-C but different ApoB; the person with higher ApoB generally has more particles capable of entering the artery wall.
Finally, the panel includes high-sensitivity C-reactive protein (hs-CRP), a marker of low-grade systemic inflammation. Inflammation does not replace lipid risk, but it can add important context—especially when you are deciding how aggressively to treat risk factors or when you are tracking overall cardiometabolic health.
Because it is a panel, the most useful interpretation comes from the combination: LDL-related markers (LDL-C, non-HDL-C, ApoB), triglycerides/HDL patterns (often linked to insulin resistance), and inflammation (hs-CRP).
What do my panel results mean?
When parts of the panel are low
“Low” can mean different things across this panel. Lower LDL-C, non-HDL-C, and ApoB are often favorable from an atherosclerosis-risk standpoint, especially if they are consistently low over time. Low triglycerides are generally favorable and often track with better insulin sensitivity and lower liver fat. Low hs-CRP is commonly a reassuring sign that you do not have elevated baseline inflammation at the time of testing. The main exception is very low HDL-C, which can be associated with insulin resistance, high triglycerides, smoking, certain medications, or genetic patterns—so it is best interpreted alongside triglycerides, waist/weight trends, and glucose markers.
When the panel looks optimal overall
An “optimal” pattern usually means LDL-related markers (especially ApoB and non-HDL-C) are in a favorable range, triglycerides are not elevated, and hs-CRP is low. In this pattern, the markers tend to agree with each other: LDL-C is not high, ApoB is not disproportionately high, and triglycerides/HDL do not suggest significant insulin resistance. If you are on lipid-lowering therapy, an optimal pattern suggests the treatment is achieving the intended direction of change, though your personal target depends on your baseline risk, family history, and any known cardiovascular disease.
When one or more parts of the panel are high
High results matter most when you look at which category is elevated and whether multiple markers point to the same risk pathway. If LDL-C and non-HDL-C are high and ApoB is also high, that pattern often suggests a higher burden of atherogenic particles and may support more intensive risk reduction. If triglycerides are high and HDL-C is low, that pattern often aligns with insulin resistance, excess refined carbohydrates/alcohol, untreated hypothyroidism, or certain medications; it may call for a different strategy than LDL-focused treatment alone. If hs-CRP is elevated, it may reflect acute illness, injury, chronic inflammatory conditions, smoking, obesity, or untreated sleep apnea; repeating hs-CRP when you are well can help distinguish a temporary spike from a persistent signal.
Factors that influence this panel
Your results can shift based on fasting status (especially triglycerides), recent alcohol intake, weight changes, and recent illness or intense exercise (which can raise hs-CRP temporarily). Medications can strongly influence the pattern: statins and ezetimibe typically lower LDL-C and ApoB; omega-3 prescriptions can lower triglycerides; some hormones, retinoids, and certain psychiatric medications can raise triglycerides. Genetics also play a major role—particularly in LDL-related markers—so a strong family history can justify deeper testing even if your starter panel looks “okay.” Finally, cardiometabolic conditions like diabetes, fatty liver disease, and hypothyroidism can distort lipid patterns, which is why follow-up testing is often guided by the full clinical picture rather than a single out-of-range value.
What’s included in this panel
- Absolute Band Neutrophils
- Absolute Basophils
- Absolute Blasts
- Absolute Eosinophils
- Absolute Lymphocytes
- Absolute Metamyelocytes
- Absolute Monocytes
- Absolute Myelocytes
- Absolute Neutrophils
- Absolute Nucleated Rbc
- Absolute Plasma Cells
- Absolute Prolymphocytes
- Absolute Promyelocytes
- Absolute Reactive Lymphocytes
- Albumin
- Albumin/Globulin Ratio
- Alkaline Phosphatase
- Alt
- Apolipoprotein B
- Ast
- Band Neutrophils
- Basophils
- Bilirubin, Total
- Blasts
- Bun/Creatinine Ratio
- Calcium
- Carbon Dioxide
- Chloride
- Chol/Hdlc Ratio
- Cholesterol, Total
- Creatinine
- Egfr
- Eosinophils
- Globulin
- Glucose
- Hdl Cholesterol
- Hdl Large
- Hematocrit
- Hemoglobin
- Homocysteine
- Hs Crp
- Iron Binding Capacity
- Iron, Total
- Ldl-Cholesterol
- Ldl Medium
- Ldl Particle Number
- Ldl Pattern
- Ldl Peak Size
- Ldl Small
- Lipoprotein (A)
- Lymphocytes
- Mch
- Mchc
- Mcv
- Metamyelocytes
- Monocytes
- Mpv
- Myelocytes
- Neutrophils
- Non Hdl Cholesterol
- Nucleated Rbc
- Phosphate (As Phosphorus)
- Plasma Cells
- Platelet Count
- Potassium
- Prolymphocytes
- Promyelocytes
- Protein, Total
- Rdw
- Reactive Lymphocytes
- Red Blood Cell Count
- % Saturation
- Sodium
- Triglycerides
- Tsh
- Urea Nitrogen (Bun)
- White Blood Cell Count
Similar and next-step cardiovascular lab panels
Frequently Asked Questions
Do I need to fast for this heart health panel?
Fasting is often recommended because triglycerides can rise after eating, which can affect calculated LDL-C and the overall lipid pattern. If you did not fast, your results can still be useful, but interpret triglycerides (and any LDL calculation) with that context. If your triglycerides are elevated on a non-fasting sample, repeating a fasting panel is a common next step.
How do I read ApoB versus LDL cholesterol on a panel?
LDL-C estimates how much cholesterol is carried inside LDL particles, while ApoB estimates how many atherogenic particles are present (each particle typically carries one ApoB). If LDL-C and ApoB are both high, the risk signal is more consistent. If LDL-C is borderline but ApoB is high, you may have more particles than LDL-C alone suggests, which can influence treatment discussions.
What does hs-CRP add if I already have cholesterol numbers?
hs-CRP adds an inflammation lens. Elevated inflammation can increase cardiovascular risk and can also reflect lifestyle and health conditions that are worth addressing (sleep, smoking, obesity, chronic inflammatory disease). Because hs-CRP can spike with infections or injuries, it is best interpreted when you are feeling well and, if elevated, often confirmed with a repeat test.
How often should I repeat this panel?
A common approach is to repeat in about 8–12 weeks after starting or changing lipid-lowering medication or making major lifestyle changes, since lipids often stabilize over that timeframe. For stable monitoring, many people recheck every 6–12 months, but your ideal cadence depends on baseline risk, family history, and whether you are actively adjusting treatment.
Is this panel enough if I have a strong family history of early heart disease?
This panel is a strong starting point, but family history can justify more detailed testing. Many people with early family events benefit from advanced lipid risk markers such as lipoprotein(a) [Lp(a)] and other particle-related measures. If your starter panel is abnormal—or if it looks normal but your family history is concerning—consider discussing an advanced lipid panel with your clinician or using PocketMD to plan next steps.
Should I order this panel or order each test separately?
Ordering a panel is usually simpler because it is designed to be interpreted as a set, and it reduces the chance that you miss a key companion marker (for example, having LDL-C without ApoB, or lipids without an inflammation signal). If you already have recent lipids and only need one follow-up marker, ordering a single test can make sense, but most first-time check-ins benefit from the bundled view.