Why is Cortisol:DHEA-S Ratio important?

This ratio is crucial for understanding adrenal health and stress response. High cortisol/DHEA-S ratio indicates chronic stress, HPA axis dysfunction, and accelerated aging. DHEA-S is protective and anabolic, while cortisol is catabolic. The ratio helps assess 'adrenal fatigue' patterns and guides treatment.

What are the symptoms of abnormal Cortisol:DHEA-S Ratio levels?

High ratio: Fatigue, poor stress tolerance, weight gain (especially abdominal), sleep disturbances, anxiety, depression, poor recovery from exercise, decreased libido.

Back to Biomarkers

Cortisol:DHEA-S Ratio

hormonal healthCalculated

HSA/FSA Eligible

Instantly book at 2,000+ locations nationwide

The Cortisol to DHEA-S ratio reflects the balance between stress hormones (cortisol) and anabolic/protective hormones (DHEA-S), indicating adrenal function and stress adaptation.

Test Cortisol:DHEA-S Ratio now

This ratio is crucial for understanding adrenal health and stress response
High cortisol/DHEA-S ratio indicates chronic stress, HPA axis dysfunction, and accelerated aging
DHEA-S is protective and anabolic, while cortisol is catabolic
The ratio helps assess 'adrenal fatigue' patterns and guides treatment

Cortisol / DHEA-S

The Cortisol to DHEA-S ratio reflects the balance between stress hormones (cortisol) and anabolic/protective hormones (DHEA-S), indicating adrenal function and stress adaptation

High ratio: Fatigue, poor stress tolerance, weight gain (especially abdominal), sleep disturbances, anxiety, depression, poor recovery from exercise, decreased libido

High ratio: Chronic stress, aging, chronic illness, sleep deprivation, overtraining, inflammation.
Low ratio: Generally favorable, indicating good stress adaptation.

This is a calculated biomarker derived from other test results in your panel. It provides additional clinical insights by combining multiple measurements into a single meaningful ratio or index.

How it works: 4 easy steps

Step01

GET STARTED

Choose your tests

Select a core panel or build a fully customized lab plan based on your health goals and concerns.

Step02

VISIT A LAB

Quick & convenient testing

Schedule your appointment at a nearby certified lab location. Most visits take just a few minutes.

Step03

REVIEW YOUR INSIGHTS

Clear, personalized results

Receive a detailed report with expert insights, actionable recommendations, and optional 1:1 guidance.

Step04

IMPROVE & MONITOR

Optimize your health

Track progress, retest when needed, and adjust your plan to continuously improve your well-being.

Our Comprehensive Panels

Essential– Start feeling better

$99/one-time

Foundation for a full basic health picture.

Check for deficiencies behind low energy and immunity
Catch heart basics before they become real issues
Find iron gaps that drive fatigue and brain fog

Advanced – Metabolic & Nutrition

$199/one-time

Deeper metabolic and nutritional insights.

Spot early metabolic issues before they become long-term problems
Uncover B12/folate gaps tied to fatigue and cognition
Balance nutrients to stabilize energy and mood

Max — Longevity & early detection

$399/one-time

Comprehensive testing for lifelong health.

Flag early cancer and inflammation signals before symptoms
Reveal hidden autoimmune and chronic stress drivers
Deep gut/liver/pancreas insights to protect longevity

Start testing at $99

Explore Other Tests

Discover more tests for deeper health insights

Basophils

Basophil percentage reflects allergic response mechanisms and immune system reactivity. Optimal levels support appropriate allergic responses without excessive inflammatory activation.

Learn More

Apolipoprotein B

ApoB represents the number of atherogenic particles in the blood, providing superior cardiovascular risk assessment compared to traditional cholesterol measurements.

Learn More

Nitrite

Urinary nitrites specifically detect nitrate-reducing bacteria, helping confirm bacterial UTIs and guide treatment decisions.

Learn More

Monocyte-to-Lymphocyte Ratio (MLR)

The Monocyte-to-Lymphocyte Ratio (MLR) is an inflammatory marker that reflects the balance between innate (monocyte) and adaptive (lymphocyte) immune responses.

Learn More

Our Customers Says

Fast booking, smooth process, and detailed results.

— Olivia Revan

Caught an issue early. I'm thankful I didn't wait.

— Denny Danaid

The results were so detailed and easy to understand.

— Sarah Mitchell

Great service! Found important health markers I didn't know about.

— Michael Chen

Quick turnaround and very professional. Highly recommend!

— Emma Johnson

Fast booking, smooth process, and detailed results.

— Olivia Revan

Caught an issue early. I'm thankful I didn't wait.

— Denny Danaid

The results were so detailed and easy to understand.

— Sarah Mitchell

Great service! Found important health markers I didn't know about.

— Michael Chen

Quick turnaround and very professional. Highly recommend!

— Emma Johnson

Have questions?

View all FAQs

Cortisol:DHEA-S Ratio

About Cortisol:DHEA-S Ratio

How It's Calculated

Why Cortisol:DHEA-S Ratio Matters

Symptoms of Cortisol:DHEA-S Ratio

What Affects Cortisol:DHEA-S Ratio Levels

How it works: 4 easy steps

Choose your tests

Quick & convenient testing

Clear, personalized results

Optimize your health

Our Comprehensive Panels

Explore Other Tests

Basophils

Apolipoprotein B

Nitrite

Monocyte-to-Lymphocyte Ratio (MLR)

Our Customers Says

Have questions?