Apo A-1 levels strongly correlate with HDL function and cardiovascular protection. Higher levels indicate better reverse cholesterol transport and reduced cardiovascular risk. It may be a better predictor of cardiovascular disease than HDL cholesterol alone.
Apo A-1 levels strongly correlate with HDL function and cardiovascular protection. Higher levels indicate better reverse cholesterol transport and reduced cardiovascular risk. It may be a better predictor of cardiovascular disease than HDL cholesterol alone.
Apolipoprotein A-1 (Apo A-1) is the primary protein component of HDL cholesterol. It plays a key role in reverse cholesterol transport, helping remove excess cholesterol from tissues back to the liver.
Reference ranges may vary slightly between laboratories. The values below represent commonly accepted clinical ranges.
Ranges shown are general guidelines. Consult your provider for personalized interpretation.
| Biomarker | Reference range | Interpretation |
|---|---|---|
Apolipoprotein A1 (Male — Optimal) | 120–160 mg/dL | Target range for optimal health |
Apolipoprotein A1 (Female — Optimal) | 120–160 mg/dL | Target range for optimal health |
Apolipoprotein A1 (Male — Standard) | 94–178 mg/dL | Standard lab reference range |
Apolipoprotein A1 (Female — Standard) | 101–199 mg/dL | Standard lab reference range |
High Apolipoprotein A1 levels above the standard range may indicate an underlying health condition that warrants further evaluation.
Low Apolipoprotein A1 levels below the standard range may indicate an underlying health condition that warrants further evaluation.
Apolipoprotein A-1 (Apo A-1) is the primary protein component of HDL cholesterol. It plays a key role in reverse cholesterol transport, helping remove excess cholesterol from tissues back to the liver.
Optimal range men: 120–160 mg/dL; women: 120–160 mg/dL. Standard range men: 94–178 mg/dL; women: 101–199 mg/dL. Always interpret ranges in clinical context, not as a stand-alone diagnosis.
Apo A-1 levels strongly correlate with HDL function and cardiovascular protection. Higher levels indicate better reverse cholesterol transport and reduced cardiovascular risk. It may be a better predictor of cardiovascular disease than HDL cholesterol alone.
Low Apo A-1: Usually asymptomatic but indicates increased cardiovascular risk. Associated with premature coronary artery disease, peripheral vascular disease, and stroke risk over time.
Low Apo A-1: Genetic disorders (Tangier disease, familial hypoalphalipoproteinemia), smoking, obesity, sedentary lifestyle, type 2 diabetes, kidney disease, uncontrolled diabetes, certain medications. High Apo A-1: Generally favorable, exercise, moderate alcohol consumption.
Apolipoprotein A1 can be ordered through Vitals Vault without a doctor referral, then completed at CLIA-certified Quest Diagnostics locations nationwide. After checkout, you receive clear draw instructions, digital requisition details, and a structured report that explains whether your result is in standard range, optimal range, or needs follow-up review.
Start by identifying the root cause, then use targeted nutrition, training, sleep, stress, and follow-up retesting to verify improvement. Apolipoprotein A1 should be optimized with a personalized plan, not guesswork.
You should speak with a clinician if Apolipoprotein A1 is significantly outside the reference range, trending in the wrong direction across repeat tests, or accompanied by symptoms like fatigue, chest discomfort, dizziness, weight change, or persistent inflammation signs. Immediate medical care is important for severe symptoms, not just abnormal numbers in isolation.
A practical retesting cadence for Apolipoprotein A1 is every 8 to 12 weeks after major lifestyle, nutrition, or medication changes, and every 3 to 6 months for stable long-term tracking. Faster cadence is useful when values are clearly abnormal, while maintenance cadence helps confirm durability once results stabilize.
You can compare Essential ($99), Advanced ($199), and Max ($399) plans during checkout to confirm Apolipoprotein A1 inclusion before purchasing. If Apolipoprotein A1 is not in your selected tier, you can upgrade plans or add targeted testing so your panel matches your goals, symptoms, and retesting strategy.
Apolipoprotein A1 is included in our comprehensive biomarker panels, processed at CLIA-certified Quest Diagnostics locations nationwide.
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Medical Disclaimer: This content is for educational and informational purposes only. It is not intended as medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with any questions about a medical condition or treatment. Do not disregard professional medical advice or delay seeking it because of information presented here.