Abalone F346 IgE (f346) blood Biomarker Testing
It measures IgE sensitization to abalone to help assess allergy risk, with easy ordering and clear results through Vitals Vault using Quest labs.
With Vitals Vault, you have access to a comprehensive range of biomarker tests.

An Abalone F346 IgE test checks whether your immune system has made IgE antibodies that recognize proteins from abalone. This is one way labs evaluate possible food allergy risk when abalone has caused symptoms or when you are trying to clarify whether it is safe for you.
This test does not “prove” you will have a reaction every time you eat abalone, and a negative result does not guarantee you will never react. Your history, the amount eaten, and other allergic conditions still matter.
If you have had rapid symptoms after eating abalone—such as hives, swelling, wheezing, vomiting, or lightheadedness—testing can help you and your clinician decide on next steps, including avoidance, broader shellfish testing, or supervised food challenge when appropriate.
Do I need a Abalone F346 IgE test?
You may want an Abalone F346 IgE test if you have symptoms that suggest an immediate-type food reaction within minutes to a few hours after eating abalone. Common patterns include itching in the mouth, hives, facial or lip swelling, cough or wheeze, stomach cramps, vomiting, or a sudden drop in blood pressure symptoms such as faintness.
Testing can also be useful if you have a history of shellfish allergy and you are trying to understand whether abalone is likely to be a problem for you. Abalone is a mollusk, and people who react to one shellfish sometimes react to others, but cross-reactivity is not uniform.
You might also consider this test if you have chronic allergic conditions (like asthma, allergic rhinitis, or eczema) and you notice flares after seafood meals, but you cannot identify the trigger. In that situation, your clinician may pair abalone IgE with other seafood-specific IgE tests and total IgE to interpret the result in context.
If you have ever had a severe reaction (trouble breathing, throat tightness, or collapse) after eating any shellfish, do not use lab results alone to decide what is safe. Testing is meant to support clinician-directed care, not self-diagnosis.
This is a laboratory-developed, CLIA-validated specific IgE blood test; results support clinical decision-making but do not diagnose allergy on their own.
Lab testing
Order Abalone F346 IgE through Vitals Vault and complete your draw at a Quest location.
Schedule online, results typically within about a week
Clear reporting and optional clinician context
HSA/FSA eligible where applicable
Get this test with Vitals Vault
Vitals Vault lets you order Abalone F346 IgE testing directly and complete your blood draw at a participating Quest location. That can be helpful when you want objective data to bring to your allergist or primary care clinician, especially if your symptoms are intermittent or you are comparing multiple possible food triggers.
After your results post, you can use PocketMD to review what “sensitization” means, how your number fits with your symptom history, and which companion tests are worth adding (for example, a broader shellfish IgE set or total IgE). If you are tracking change over time—such as after a long period of avoidance—PocketMD can also help you plan a sensible retest interval.
If your result suggests higher risk, the next step is usually a safety plan rather than guesswork. That may include strict avoidance, label-reading strategies, and a discussion with your clinician about whether you should carry emergency medication based on your reaction history.
- Order online and draw at a Quest location
- Results you can share with your clinician
- PocketMD guidance for next-step planning
Key benefits of Abalone F346 IgE testing
- Helps identify IgE sensitization to abalone when symptoms follow abalone exposure.
- Supports safer food decisions when you have a known shellfish allergy history.
- Clarifies whether abalone is a likely trigger when reactions happen after mixed seafood meals.
- Guides whether broader shellfish testing (mollusks and crustaceans) may be useful.
- Provides an objective baseline you can trend if you avoid abalone and later reassess risk.
- Helps your clinician interpret symptoms alongside other allergy markers like total IgE.
- Creates a clear, shareable lab record you can review with PocketMD and your care team.
What is Abalone F346 IgE?
Abalone F346 IgE is a blood test that measures allergen-specific immunoglobulin E (IgE) antibodies directed against abalone proteins. IgE is the antibody class involved in immediate hypersensitivity reactions, where symptoms can appear quickly after exposure.
A positive abalone-specific IgE result means your immune system recognizes abalone proteins and has produced IgE against them. This is called sensitization. Sensitization increases the likelihood of an allergic reaction, but it is not the same as a confirmed clinical allergy.
A negative result means the test did not detect abalone-specific IgE above the lab’s threshold. That lowers the probability of an IgE-mediated abalone allergy, but it does not fully rule it out, especially if your reaction was recent, you have very high total IgE, or your symptoms were not classic for IgE-mediated allergy.
IgE sensitization vs. true allergy
True food allergy is diagnosed by combining your history (what happened, how fast, how reproducible), exam, and testing. Specific IgE supports the picture, but your clinician may still recommend skin testing or a supervised oral food challenge if the risk-benefit makes sense.
Why abalone can be confusing in “shellfish allergy”
“Shellfish” includes crustaceans (like shrimp and crab) and mollusks (like clams, oysters, scallops, and abalone). Some people react broadly, while others react to only one group. Cross-reactivity can occur because some proteins are similar across species, but the pattern is individual.
What do my Abalone F346 IgE results mean?
Low Abalone F346 IgE
A low or undetectable result generally means abalone-specific IgE was not found above the lab cutoff. If your symptoms were mild, delayed, or inconsistent, this may point away from an IgE-mediated abalone allergy and toward other explanations (intolerance, food poisoning, histamine reactions, or another ingredient). If you had a convincing immediate reaction, your clinician may still consider additional testing or a supervised challenge because no single test is perfect.
In-range / negative Abalone F346 IgE
For specific IgE tests, “optimal” usually means negative or not elevated, because the goal is to see whether sensitization is present. A negative result is most reassuring when your history does not strongly suggest an immediate allergic reaction. If you are avoiding abalone due to uncertainty, a negative result can be a useful data point to discuss with your clinician before reintroducing it.
High Abalone F346 IgE
An elevated result indicates sensitization to abalone and increases the likelihood that abalone could trigger an allergic reaction. Higher values often correlate with higher probability of clinical allergy, but they do not reliably predict reaction severity. If you have asthma, prior anaphylaxis, or reactions to other shellfish, your clinician may treat a positive result more cautiously and may recommend broader shellfish evaluation and a clear emergency plan.
Factors that influence Abalone F346 IgE
Your result is influenced by your immune system’s overall allergic tendency, including conditions like eczema, allergic rhinitis, and asthma. Cross-reactivity with other shellfish or environmental allergens can sometimes contribute to a positive result even if you do not react clinically. Recent exposures, long-term avoidance, and age can shift IgE levels over time, which is why trends are sometimes more informative than a single number. Medications like antihistamines do not typically affect blood IgE results, but they can mask symptoms and complicate history-based interpretation.
What’s included
- Abalone (F346) Ige
Frequently Asked Questions
Do I need to fast for an Abalone F346 IgE blood test?
Fasting is not usually required for specific IgE testing. If you are combining this with other labs (like lipids or glucose), follow the instructions for the full order.
What does a positive Abalone IgE mean?
A positive result means you are sensitized to abalone, meaning your immune system has made IgE antibodies that recognize abalone proteins. It raises the likelihood of an allergic reaction, but your symptoms and history are still needed to confirm a true food allergy.
Can a negative Abalone IgE rule out an abalone allergy?
Not completely. A negative result makes an IgE-mediated abalone allergy less likely, but false negatives can happen. If you had a clear immediate reaction, talk with your clinician about whether additional testing or supervised food challenge is appropriate.
Is abalone considered shellfish, and does this test cover other shellfish?
Abalone is a mollusk. This test is specific to abalone and does not automatically test shrimp, crab, lobster, clam, oyster, or scallop. If you need a broader view, your clinician may recommend additional shellfish-specific IgE tests.
How soon after a reaction should I test IgE?
You can usually test at any time because specific IgE reflects sensitization rather than an acute reaction marker. If your reaction was very recent and results do not fit your story, your clinician may suggest repeating later or using complementary testing.
How often should I retest Abalone F346 IgE?
Retesting is most useful when it would change a decision, such as considering reintroduction after long-term avoidance or monitoring a child who may outgrow a food allergy. Many clinicians consider intervals like 6–12 months or longer depending on age, history, and prior levels.