Free lab panel at month 3Start by Jan 31

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Progesterone Capsules

Capsule · 100 mg / 200 mg

Protect your uterine lining while you take estrogen, with a bedtime capsule that matches your own hormone.

$1.94/dayBilled $349 every 180 days

Start my $20 doctor visit

Medication is charged only if your clinician prescribes it.

US clinicians
Licensed pharmacy
LegitScript
$20 review refunded
Free discreet shipping

Protects the uterus while you take estrogen
Same structure as the progesterone your body makes
One bedtime capsule, 100 mg or 200 mg

Recommended lab testing

Not required to start. Your clinician may suggest it to tailor and monitor your care.

Women’s Proof Panel · $169.00

See the 17 tests included

Urinalysis with Reflex to Microscopic, Thyroid Panel with TSH, Iron, TIBC and Ferritin Panel, Testosterone, Free (Dialysis) and Total, MS, Uric Acid, hs-CRP, Vitamin D, 25-Hydroxy, Total, Immunoassay, Hemoglobin A1c with eAG, Comprehensive Metabolic Panel, Sed Rate by Modified Westergren, CBC (includes Differential and Platelets), Lipid Panel, Cardio IQ, Estradiol, FSH and LH, Progesterone, Immunoassay, DHEA Sulfate, Immunoassay, Sex Hormone Binding Globulin (SHBG)

Recommended for your care.

For this recommendation, results within 90 days can be reviewed.

Already have results?

Upload your results after you start, and your care team will review them.

Panel prices and any applicable lab visit fees are confirmed in checkout.

Choose your plan90-day supplyBilled $199 every 90 days$2.22per day180-day supplyBest value · Save $0.28/dayBilled $349 every 180 days$1.94per day

Start with a $20 clinician review

The review fee is refunded if you’re not prescribed. Medication is billed separately only if prescribed.

Start my $20 doctor visit

Prescribed only if appropriate. Compounded medications are not FDA-approved. Review the full terms in checkout.

What the research shows

6% vs 64%

had endometrial hyperplasia on estrogen plus progesterone versus estrogen alone over 36 months in the label trial

Source: Prometrium (progesterone) capsules prescribing information, DailyMed

34% vs 1%
had adenomatous or atypical hyperplasia on estrogen alone versus estrogen plus a progestin (875 women, 3 years)
Source: The Writing Group for the PEPI Trial. JAMA 1995;273(3):199-208 (randomized trial)
0.9 vs 1.4
relative breast cancer risk with estrogen plus micronized progesterone versus plus synthetic progestins, in 54,548 women
Source: Fournier A, et al. Int J Cancer 2005;114(3):448-54 (E3N cohort, observational)

The 6% and 64% figures come from the label trial of Prometrium 200 mg for 12 days a month with conjugated estrogens; your clinician sets your own dose and schedule. The French cohort is observational: it shows an association, not proof, and estrogen with progesterone still carries a boxed warning. These studies used FDA-approved products, and our capsule was not part of them. Individual results vary.

The Bedtime Uterine Protection Plan

Take estrogen with your uterine lining protected, on a schedule your clinician sets for you, with one capsule at bedtime delivered to your door.

Everything included

Clinician review of your estrogen plan
A US-licensed clinician checks that progesterone fits your history, and prescribes only if it does.
Your capsules, filled
100 mg or 200 mg micronized progesterone capsules from a licensed US pharmacy, in a 90 or 180-day supply.
A schedule set for you
Daily or on set days of the month, chosen by your clinician and changeable later.
Free, discreet shipping
Plain packaging to your door, 2 to 5 business days after approval.
Your care team on message
Report bleeding, drowsiness or other side effects any time, and your clinician can change the plan.

Bonuses

Free lab panel at month 3
Menopause Check, as a progress check.
“I do not want two different prescribers.”
Estradiol and progesterone under one clinician
Both are prescribed here, so your estrogen and its uterine protection stay in one plan and one inbox.
“What if something feels off?”
Message us about bleeding
Unexpected bleeding is the symptom worth reporting early, and your care team is a message away.

Labs we cover

Menopause Check

Start or transfer your treatment between Nov 1 and Jan 31 and get this panel free at your 3-month mark. Labs are a bonus, not needed to start treatment.

How progesterone joins your plan

Estrogen makes the lining of your uterus grow. On its own it can overgrow and raise the risk of uterine cancer, so women with a uterus take progesterone alongside it to keep that lining in check.

Micronized progesterone is chemically identical to the progesterone your ovaries make, in a bedtime capsule. Your clinician chooses 100 mg or 200 mg and the schedule.

One capsule at bedtime. Taken at night because it can make you drowsy. Your clinician chooses a daily or cyclic schedule.

Step 1
Start with your estrogen plan
If you take estrogen and still have a uterus, progesterone protects it. Tell us what you take now.
About 5 minutes
Step 2
Clinician sets the schedule
They choose 100 mg or 200 mg, and daily or on set days of the month, after reviewing your history.
Reviewed within 24 hours
Step 3
Take it at bedtime
If prescribed, capsules ship free in plain packaging. Drowsiness is a known effect, so night dosing works with it.
Ships in 2 to 5 business days
Step 4
Check in
Report any unexpected bleeding right away. Your care team adjusts the plan with you.

A Middle Eastern woman in her late 30s with long dark hair cooling off by an open window, at ease

What to expect

Before you start
Your clinician confirms you take estrogen, still have a uterus and have no peanut allergy.
First weeks
Drowsiness, dizziness, bloating and breast tenderness are the common early effects. Tell your care team if they stay.
Sleep
In a 189-woman perimenopause trial, women reported better sleep and fewer night sweats on progesterone, though its main hot flash score did not differ from placebo.
Any time
Report vaginal bleeding you did not expect, and you and your clinician review the plan regularly.

What makes it work better

Three things you can do alongside your treatment.

Make bedtime a wind-down
Help your body clear estrogen
Steady your stress rhythm

Progesterone, a progestin, or nothing

Feature	Micronized progesterone	Synthetic progestin	No progestogen with estrogen
What it is	Same structure as the progesterone your ovaries make	A related, man-made compound, for example medroxyprogesterone	Estrogen alone
Protects the uterine lining if you have a uterus	Yes	Yes	No; raises endometrial cancer risk
Usual timing	Bedtime	Any time of day	Not applicable
Peanut allergy	Not suitable (capsules contain peanut oil)	Depends on the product	Not applicable
Right for you if	You have a uterus, take estrogen and have no peanut allergy	A different progestin suits your history better	You have had a hysterectomy

Your clinician picks based on your history.

Before you start

For women with a uterus who take estrogen. Its main job is protecting the uterine lining.
Not for anyone with a peanut allergy, unexplained vaginal bleeding, a history of breast cancer, a past blood clot, stroke or heart attack, or liver disease.
It can make you drowsy or dizzy. Take it at bedtime and do not drive if you feel sleepy.
Taken with estrogen, it falls under the estrogen plus progestin boxed warning for heart disease, stroke, breast cancer, clots and dementia. Your clinician reviews it with you.

How to take it

Take 1 capsule by mouth at bedtime, 100 mg or 200 mg as prescribed. Your clinician chooses a daily or cyclic schedule with your estrogen and can change it later.

Side effects and safety

Estrogen with a progestin should not be used to prevent heart disease or dementia. In the Women's Health Initiative, the combination raised the risk of blood clots in the legs and lungs, stroke and heart attack. It also raised the risk of invasive breast cancer, and of probable dementia in women aged 65 and over.

Tell your care team straight away if you get chest pain or shortness of breath, pain or swelling in a leg, sudden vision change or loss, a sudden severe headache or weakness on one side, a new breast lump, or yellowing of your skin or eyes.

Common side effects

headache
breast tenderness
dizziness
low mood
abdominal pain
breast pain
drowsiness
bloating

Rare but serious

blood clots in the legs or lungs
stroke
heart attack
invasive breast cancer
probable dementia in women aged 65 and over
vision problems

Do not take this if you are allergic to peanuts, because the capsules contain peanut oil. Also do not take it if you have unexplained vaginal bleeding, you have or have had breast cancer, you have had a blood clot in a leg or lung, you have had a stroke or heart attack, or you have liver disease.

This is not a complete list of side effects. Message your care team about any symptom that worries you.

Your questions, answered.

A white woman in her late 40s with shoulder-length auburn hair reading a message from her care team

Why do I need progesterone with estrogen?

Estrogen alone raises the risk of overgrowth and cancer of the uterine lining. Progesterone protects it. In the label trial, hyperplasia was 6% with progesterone versus 64% with estrogen alone.

Why take it at night?

It can cause drowsiness and dizziness, so the label directs a single daily dose at bedtime. Do not drive if you feel sleepy.

Can progesterone replace estrogen for hot flashes?

Not as a first choice. Hormone therapy with estradiol is the most effective treatment for hot flashes and night sweats. Progesterone alone has been tested for hot flashes with mixed results, and its main job here is protecting your uterus.

Is it the same as a synthetic progestin?

No. Micronized progesterone has the same structure as the hormone your body makes, while progestins are related compounds. Both protect the uterus, and your clinician picks the one that fits your history.

What side effects are common?

Headache, breast tenderness, dizziness, drowsiness, bloating and mood changes. Tell your care team about any bleeding you did not expect or a new breast lump.

I don't have a uterus. Do I need it?

Usually not for uterine protection. Your clinician will advise.

I'm allergic to peanuts. Can I take it?

No. The capsules contain peanut oil, and the label lists peanut allergy as a reason not to take them. Your clinician can discuss other options.

Daily or only some days of the month?

Either can be used with estrogen. Your clinician chooses a daily or cyclic schedule from your history and symptoms, and can change it later.

The Bedtime Uterine Protection Plan

Reviewed by a US-licensed clinician, and prescribed only if it suits you
Filled by a licensed US pharmacy
Free, discreet shipping to your door
LegitScript certified, and rated 4.5 on Google

180-day supply · $1.94/day · Billed $349 every 180 days

Start my $20 doctor visit

$20 review refunded if not prescribed
Cancel anytime
Full refund before your blood draw
Free, discreet shipping

Progesterone Capsules

What the research shows

The Bedtime Uterine Protection Plan

Everything included

Bonuses

Labs we cover

How progesterone joins your plan

Start with your estrogen plan

Clinician sets the schedule

Take it at bedtime

Check in

What to expect

Before you start

First weeks

Sleep

Any time

What makes it work better

Make bedtime a wind-down

Help your body clear estrogen

Steady your stress rhythm

Progesterone, a progestin, or nothing

Before you start

How to take it

Side effects and safety

Your questions, answered.

The Bedtime Uterine Protection Plan