Free lab panel at month 3Start by Jan 31

4.5 on Google

Estradiol Oral Capsule

Capsule · 1.1 mg

Fewer hot flashes and night sweats from one daily capsule, prescribed online by a licensed clinician.

$1.94/dayBilled $349 every 180 days

Start my $20 doctor visit

Medication is charged only if your clinician prescribes it.

US clinicians
Licensed pharmacy
LegitScript
$20 review refunded
Free discreet shipping

Fewer hot flashes and night sweats
One capsule a day, no patch to change
Supports bone health and sleep

Recommended lab testing

Not required to start. Your clinician may suggest it to tailor and monitor your care.

Women’s Proof Panel · $169.00

See the 17 tests included

Urinalysis with Reflex to Microscopic, Thyroid Panel with TSH, Iron, TIBC and Ferritin Panel, Testosterone, Free (Dialysis) and Total, MS, Uric Acid, hs-CRP, Vitamin D, 25-Hydroxy, Total, Immunoassay, Hemoglobin A1c with eAG, Comprehensive Metabolic Panel, Sed Rate by Modified Westergren, CBC (includes Differential and Platelets), Lipid Panel, Cardio IQ, Estradiol, FSH and LH, Progesterone, Immunoassay, DHEA Sulfate, Immunoassay, Sex Hormone Binding Globulin (SHBG)

Recommended for your care.

For this recommendation, results within 90 days can be reviewed.

Already have results?

Upload your results after you start, and your care team will review them.

Panel prices and any applicable lab visit fees are confirmed in checkout.

Choose your plan90-day supplyBilled $199 every 90 days$2.22per day180-day supplyBest value · Save $0.28/dayBilled $349 every 180 days$1.94per day

Start with a $20 clinician review

The review fee is refunded if you’re not prescribed. Medication is billed separately only if prescribed.

Start my $20 doctor visit

Prescribed only if appropriate. Compounded medications are not FDA-approved. Review the full terms in checkout.

What the research shows

75%
reduction in weekly hot flashes versus placebo, pooled from 24 trials of oral hormone therapy in 3,329 women
Source: Maclennan AH, et al. Cochrane Database Syst Rev 2004;(4):CD002978 (meta-analysis)
7.4 years
median length of frequent hot flashes and night sweats across the menopause transition (1,449 women)
Source: Avis NE, et al. JAMA Intern Med 2015;175(4):531-9 (SWAN cohort)
8.6% vs 11.1%
of women had a fracture on estrogen plus progestin versus placebo over 5.6 years in the 16,608-woman WHI trial
Source: Cauley JA, et al. JAMA 2003;290(13):1729-38 (randomized trial)
Under 60
or within 10 years of menopause: when benefits generally outweigh risks for healthy women
Source: The Menopause Society, Menopause 2022;29(7):767-94 (position statement)

Figures come from trials and guidelines on FDA-approved hormone therapy. Our capsule is compounded by a licensed US pharmacy, is not FDA approved, and was not studied in them. The fracture trial used conjugated estrogens with a progestin, and the same trial found higher risks of stroke, blood clots and breast cancer (see safety). Individual results vary.

The Hot Flash Relief Plan

Fewer hot flashes and night sweats, quieter nights, and a clinician who tunes your dose with you, without a trip to an office.

Everything included

Licensed clinician review
A US-licensed clinician reads your symptoms, age and history, and prescribes only if estradiol fits.
Your prescription, filled
1.1 mg estradiol capsules compounded by a licensed US pharmacy, in a 90 or 180-day supply.
Uterine protection planned for you
If you have a uterus, your clinician adds progesterone, available here as its own prescription.
Free, discreet shipping
Plain packaging to your door, 2 to 5 business days after approval.
Your care team on message
Ask about side effects or your dose any time, and your clinician can change it.

Bonuses

Free lab panel at month 3
Menopause Check, as a progress check.
“Extra tests will add up.”
No lab visit fee for treatment members
If you want a baseline lipid, glucose or vitamin D check, book one Quest visit near you without the usual visit fee.
“What if one product is not enough?”
Pill, progesterone and cream under one clinician
Estradiol, progesterone and vaginal estrogen are all prescribed here, so your plan can change without changing company.

Labs we cover

Menopause Check

Start or transfer your treatment between Nov 1 and Jan 31 and get this panel free at your 3-month mark. Labs are a bonus, not needed to start treatment.

From first question to first capsule

Hot flashes and night sweats come from the fall in estradiol at menopause, which makes the temperature control in your brain easier to trip. The same drop affects sleep, mood, bone and vaginal tissue, because estradiol signals to all of them.

Oral estradiol replaces that signal with a daily capsule of the main estrogen your ovaries make. Hormone therapy remains the most effective treatment for hot flashes and night sweats, and your clinician picks the lowest dose that works.

One capsule a day. Your dose is tuned to how you feel and to your follow-up labs. Progesterone is added when your uterus needs protecting.

Step 1
Answer a few questions
Hot flashes, sleep, mood, periods and your health history. About 5 minutes, all online.
About 5 minutes
Step 2
A clinician checks your fit
They look at your age, time since your last period, and any clot, stroke or breast cancer history, and add progesterone if you have a uterus.
Reviewed within 24 hours
Step 3
One capsule a day, delivered
If prescribed, your 1.1 mg estradiol capsules ship free in plain packaging.
Ships in 2 to 5 business days
Step 4
Adjust with your clinician
Hot flashes tend to ease first. Message your care team about side effects, and your dose is reviewed at follow-ups.

A white woman in her late 40s with shoulder-length auburn hair cooling off by an open window, at ease

What to expect

First 4 weeks
In a 12-week trial of 333 women, the typical woman on 1 mg oral estradiol had 86% fewer moderate to severe hot flashes by week 4, versus 52% fewer on placebo.
Weeks 4 to 12
Night sweats ease and sleep often follows. Your clinician checks in and adjusts your dose if you need it.
Early side effects
Breast tenderness, nausea and headache are the common ones. Tell your clinician if they persist.
Every year
You and your clinician review the benefits and risks and keep to the lowest dose that works.

What makes it work better

Three things you can do alongside your treatment.

Keep the night cool and regular
Turn down the stress signal
Protect bone, lipids and vitamin D

Pill, patch or cream

Feature	Oral estradiol capsule	Estradiol patch	Vaginal estrogen cream
How you use it	One capsule a day	A patch changed once or twice a week	Applied inside the vagina, daily at first, then a few times a week
Hot flashes and night sweats	Treats them	Treats them	Does not treat them
Vaginal dryness and painful sex	Often improves	Often improves	Treats it directly
Route and risk	Passes through the liver first, which can raise triglycerides and clotting factors	Skips the liver; often chosen when clot risk or triglycerides are a concern	Low dose applied where it is needed
Progesterone if you have a uterus	Yes	Yes	Usually not at low vaginal doses; your clinician decides
Offered by Vitals Vault	Yes	Not yet; ask your clinician if a patch suits you better	Yes, as its own product

Route is a clinical decision. The Menopause Society notes that hormone therapy risks differ by type, dose, duration, route and timing.

Before you start

Usually for women under 60 or within 10 years of their last period.
If you have a uterus, progesterone is prescribed with it.
Not for anyone with breast cancer, a past blood clot, stroke or heart attack, liver disease or unexplained vaginal bleeding, or who is or may be pregnant.
On thyroid medicine? Oral estrogen can change how much you need, so tell your clinician.
Estrogen carries a boxed warning for endometrial cancer, heart disease, breast cancer and dementia. Your clinician reviews it with you.
This capsule is compounded by a licensed US pharmacy and is not FDA approved. It is prescribed only if it is right for you.

How to take it

Take 1 capsule (1.1 mg) by mouth once daily, as prescribed. Your clinician sets your dose and adjusts it after follow-ups. If you have a uterus, progesterone is prescribed alongside it.

Side effects and safety

Estrogen raises the risk of cancer of the uterus lining. Estrogen, with or without a progestin, should not be used to prevent heart disease or dementia. In the Women's Health Initiative, estrogen alone raised the risk of stroke and blood clots in the legs, and estrogen with a progestin raised the risk of heart attack, stroke, invasive breast cancer, and blood clots in the lungs and legs.

Tell your care team straight away if you get any unusual vaginal bleeding, chest pain or shortness of breath, pain or swelling in a leg, sudden vision loss or change, a sudden severe headache or weakness on one side, yellowing of your skin or eyes, or swelling of your face, lips or throat.

Common side effects

nausea and vomiting
breast tenderness or enlargement
headache
abdominal cramps
changes in vaginal bleeding
dizziness
low mood
hair loss
darkening of the skin

Rare but serious

cancer of the uterus lining
breast cancer
ovarian cancer
stroke and heart attack
blood clots in the legs or lungs
gallbladder disease needing surgery
probable dementia in women aged 65 and over

Do not take this if you have unexplained vaginal bleeding, you have or have had breast cancer or another estrogen-dependent cancer, you have had a blood clot in a leg or lung, you have had a stroke or heart attack, you have liver disease, or you are or may be pregnant.

This is not a complete list of side effects. Message your care team about any symptom that worries you.

Your questions, answered.

Is hormone therapy safe?

For healthy women under 60 or within 10 years of menopause, The Menopause Society says the benefits generally outweigh the risks. Estrogen does carry a boxed warning for endometrial cancer, heart disease, breast cancer and dementia, so a clinician reviews your history before prescribing, and you can stop at any time.

What is the 1.1 mg capsule?

It is estradiol, the main estrogen your ovaries make, in a once-a-day capsule compounded by a licensed US pharmacy. It sits just above the common 1 mg tablet strength. It is not FDA approved and was not itself studied in the trials we cite, and your clinician adjusts the dose to how you feel.

What about breast cancer?

In the Women's Health Initiative, estrogen plus a progestin raised the risk of invasive breast cancer, and estrogen is not for you if you have had breast cancer. Your clinician reviews your personal and family history first.

Do I need progesterone too?

If you have a uterus, yes. Estrogen alone raises the risk of cancer of the uterine lining, and progesterone protects it. If you have had a hysterectomy you usually do not need it. We offer micronized progesterone as its own prescription.

Will it help me sleep?

Night sweats wake many women, and when they ease, sleep often gets a chance to recover. Estrogen is not a sleep medicine, so tell your clinician if sleep stays poor; the sleep habits under what to expect help with both.

Do I need blood tests to start?

Usually not. Menopause is diagnosed from your symptoms, age and periods. Your clinician may suggest checks such as blood pressure, a lipid panel, fasting glucose and vitamin D, mainly because oral estrogen can raise triglycerides. Labs are available through Vitals Vault if you want a baseline.

Can I start before my periods stop?

Many women start in perimenopause, when symptoms often begin. Your clinician decides from your symptoms, cycle and history.

How long will I take it?

There is no fixed limit. You and your clinician review the benefits and risks regularly and keep to the lowest dose that works for you. Talk to your clinician before you stop.

The Hot Flash Relief Plan

Reviewed by a US-licensed clinician, and prescribed only if it suits you
Filled by a licensed US pharmacy
Free, discreet shipping to your door
LegitScript certified, and rated 4.5 on Google

180-day supply · $1.94/day · Billed $349 every 180 days

Start my $20 doctor visit

$20 review refunded if not prescribed
Cancel anytime
Full refund before your blood draw
Free, discreet shipping

Estradiol Oral Capsule

What the research shows

The Hot Flash Relief Plan

Everything included

Bonuses

Labs we cover

From first question to first capsule

Answer a few questions

A clinician checks your fit

One capsule a day, delivered

Adjust with your clinician

What to expect

First 4 weeks

Weeks 4 to 12

Early side effects

Every year

What makes it work better

Keep the night cool and regular

Turn down the stress signal

Protect bone, lipids and vitamin D

Pill, patch or cream

Before you start

How to take it

Side effects and safety

Your questions, answered.

The Hot Flash Relief Plan