A nightly retinoid cream with niacinamide, prescribed for fine lines, tone and texture.
$1.28/dayBilled $229 every 180 days
Medication is charged only if your clinician prescribes it.
Start with a $20 clinician review
50 women
in a 12-week split-face trial where 5% niacinamide reduced fine lines, spots and blotchiness
Source: Bissett et al., Dermatol Surg 20053-4 months
before most people notice effects of tretinoin; up to 6 months for some
Source: Renova label (FDA)SPF daily
sunscreen and sun protection are part of tretinoin use, per its FDA label
Source: Renova label (FDA)Our concentration may differ. FDA label for Renova 0.05%; our strength and base differ. Individual results vary.
Prescription tretinoin with niacinamide, started gently and adjusted with a clinician, delivered every 90 or 180 days.
Clinician review of your skin and history
A US-licensed clinician checks your answers, sensitivity and pregnancy plans before prescribing.
Tretinoin 0.05% with niacinamide, compounded in a US pharmacy
A 30 g tube of cream per fill, in a 90-day or 180-day plan.
A built-in ramp-up schedule
Directions start at two or three nights a week and build up as your skin tolerates.
Free, discreet shipping
Ships 2 to 5 business days after approval.
Care team messaging
Ask about dryness, peeling or breakouts and your clinician can change the plan.
Free lab panel at month 3
Biological Age Reveal, as a progress check.
“Retinoids irritate my skin.”
Niacinamide already in the tube
One nightly step instead of mixing products yourself.
“I do not want to book a dermatologist.”
No office visit
The whole review is online.
Biological Age Reveal
Tretinoin speeds up how fast skin cells turn over. That clears blocked pores, and over months it can smooth texture and soften fine lines.
It is also the topical retinoid most likely to irritate, which is why niacinamide is in the cream and why you build up the number of nights slowly. Daily sunscreen protects the skin you are renewing.
A pea-sized amount, at night. Start two or three nights a week and build up as your skin adjusts. Daily sunscreen is part of the plan.
Concerns, sensitivity, current products and pregnancy plans.
They pick a strength and a ramp-up plan.
A pea-sized amount at night; build up as your skin adjusts.
Expect gradual change over months.
Dryness, redness or a temporary flare of breakouts is common while your skin adjusts. Back off a night or two if it feels raw.
For acne, the label says improvement can start after 2 to 3 weeks, and more than 6 weeks may be needed for a clear benefit.
For fine lines and texture, effects typically begin to show around 3 to 4 months, and up to 6 months may be needed.
Gains can fade if you stop, and use beyond a year has not been formally studied.
Three things you can do alongside your treatment.
A gentle cleanser and a daily moisturizer keep the barrier intact, which is what tretinoin tests in the first weeks. A stronger barrier means fewer dropouts.
Stress, gut health and the immune system all feed into skin. A food pattern built on anti-inflammatory foods, steady sleep and a stress outlet give the cream a better starting point.
Sun exposure is the main driver of photoaging and makes retinoid-treated skin burn more easily. A daily broad-spectrum sunscreen and a hat protect the progress you are building.
| Feature | Tretinoin + niacinamide | Over-the-counter retinol |
|---|---|---|
| Active form | Tretinoin, the active form of vitamin A | A precursor the skin converts |
| Prescription | Yes | No |
| Strength | Clinician-chosen | Varies by product |
| Irritation early on | Common; niacinamide and a slow start help | Usually milder |
Tretinoin helps soften fine lines; it does not reverse sun damage. Compounded, not FDA-approved as a combination.
Apply a pea-sized amount of the 0.05% cream to a clean, dry face at night, starting two to three nights a week and building up as tolerated. Use sunscreen every morning.
Tretinoin is FDA approved for acne. This preparation is compounded with niacinamide, so the combination has not been reviewed by the FDA.
Tell your care team straight away if your skin blisters or crusts, you get severe swelling, burning or stinging you cannot tolerate, you get sunburned while using it, or peeling keeps getting worse.
Common side effects
Rare but serious
Do not take this if you are pregnant, or your skin is sunburned or has active eczema.
This is not a complete list of side effects. Message your care team about any symptom that worries you. What we dispense is a compounded preparation made by a licensed US pharmacy. Compounded medications are not approved by the FDA for safety, efficacy or quality.
Tretinoin can soften fine lines and improve texture over months. Its FDA label is clear that it does not remove wrinkles or repair sun-damaged skin.
Dryness, peeling or a few breakouts in the first weeks are common. Starting slowly helps.
No. Retinoids are not used in pregnancy. Tell your clinician if you are pregnant, trying or breastfeeding.
It is a well-tolerated vitamin B3 that reduced fine lines and spots in a 12-week trial in women, and it pairs well with retinoids.
A gentle cleanser, moisturizer and SPF 30 daily. Skip other retinoids and harsh exfoliants unless your clinician says so.
Texture and tone change gradually, usually over a few months.
180-day supply · $1.28/day · Billed $229 every 180 days
