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Treatments / Tirzepatide + B12
Free lab panel at month 3Start by Jan 31
Tirzepatide + B12 injection package

4.5 on Google

Tirzepatide + B12

Compounded tirzepatide with glycine and B12: a weekly injection that works on two appetite hormones and supports steady weight loss alongside food and movement changes. Prescribed after a licensed clinician reviews your history.

One weekly injection that targets two appetite hormones, with B12 in every dose. Prescribed online if it fits.

$42.25/weekBilled $169 every 4 weeks

Start my $20 doctor visit

Medication is charged only if your clinician prescribes it.

Free lab panel with your treatment Start by Jan 31

Metabolic Check

Given at your 3-month mark as a progress check.

  • US clinicians
  • Licensed pharmacy
  • LegitScript
  • $20 review refunded
  • Free discreet shipping
  • Targets two appetite hormones, GIP and GLP-1
  • B12 added to help reduce fatigue
  • Dose stepped up slowly by your clinician

Recommended lab testing

Not required to start. Your clinician may suggest it to tailor and monitor your care.

RX-Metabolic Panel · $37.99

See the 27 tests included

Hemoglobin A1c, LDL:HDL Ratio, Total Cholesterol, HDL Cholesterol, Triglycerides, LDL Cholesterol, Cholesterol/HDL ratio, Non HDL Cholesterol, eGFR, Glucose, Urea Nitrogen (Bun), Creatinine, BUN/Creatinine Ratio, Sodium, Potassium, Chloride, Carbon Dioxide, Calcium, Total Protein, Albumin, Globulin, Albumin/Globulin Ratio, Total Bilirubin, Alkaline Phosphatase, AST, ALT, TSH

Recommended for your care.

For this recommendation, results within 90 days can be reviewed.

Already have results?

Upload your results after you start, and your care team will review them.

Panel prices and any applicable lab visit fees are confirmed in checkout.

Every 28 days

$42.25/week

Billed $169 every 4 weeks · Cancel anytime

  • Injection · 10 mg/mL (tirzepatide)
  • Free, discreet shipping

Free shipping with prescribed treatment.

Today you only pay a $20 clinician review, refunded if you’re not prescribed. Your plan starts only if prescribed.

Prescribed only if appropriate · Compounded medications are not FDA-approved.

Start my $20 doctor visit

What the research shows

15% to 21%

average body weight lost at 72 weeks on branded tirzepatide 5, 10 and 15 mg, vs 3.1% on placebo

Source: Jastreboff AM, et al. SURMOUNT-1, N Engl J Med 2022;387(3):205-16

  • 20.2% vs 13.7%

    average weight lost at 72 weeks, branded tirzepatide vs branded semaglutide, head to head

    Source: Aronne LJ, et al. SURMOUNT-5, N Engl J Med 2025;393(1):26-36 (open-label)

  • 85% to 91%

    lost at least 5% of their body weight at 72 weeks across the three doses, vs 35% on placebo

    Source: Jastreboff AM, et al. SURMOUNT-1, N Engl J Med 2022;387(3):205-16

  • 57%

    lost 20% or more of their body weight on the 15 mg dose at 72 weeks, vs 3% on placebo

    Source: Jastreboff AM, et al. SURMOUNT-1, N Engl J Med 2022;387(3):205-16

Results from trials of FDA-approved tirzepatide in adults without diabetes, with diet and activity support. Our tirzepatide is compounded by a licensed US pharmacy, includes glycine and B12, is not FDA approved and was not studied in these trials. Individual results vary.

Weight kept coming down for those who stayed on it

Average body weight lost: Day 1 0%, Week 36 20.9%, Week 88 25.3%

Day 1Week 36Week 880%20.9%25.3%
Average body weight lost

Source: Aronne LJ, et al. SURMOUNT-4, JAMA 2024;331(1):38-48 (branded tirzepatide, continued group) · Group average in a trial where everyone took the top tolerated dose for 36 weeks first, then half kept going. Not a prediction for you.

The Two-Hormone Weight Plan

Two appetite hormones targeted by one weekly injection, with B12 and glycine already in the vial and a clinician who steps your dose up for you.

Everything included

  • Licensed clinician review

    A US-licensed clinician reads your history, goals and medicines, and prescribes only if tirzepatide fits.

  • Your prescription, filled

    Compounded tirzepatide with glycine and B12, made by a licensed US pharmacy and sent in 28-day supplies.

  • Free, discreet shipping

    Plain packaging to your door, 2 to 5 business days after approval.

  • Dose steps built in

    Your clinician raises your dose in small steps, at least four weeks apart, and each supply matches your current dose.

  • Your care team on message

    Ask about nausea, appetite or your next step at any point, and your clinician can change the plan.

  • Semaglutide on the table too

    We offer both medicines, so your clinician can switch the recommendation if tirzepatide is not the right fit.

Bonuses

  • Free lab panel at month 3

    Metabolic Check, as a progress check.

  • “Faster weight loss worries me: I'm afraid of feeling drained and losing muscle.”

    B12 and glycine in every dose

    Added by the prescriber to help reduce fatigue and muscle loss during weight loss, with nothing extra to buy or remember.

  • “I'd like numbers, not just the scale.”

    No lab visit fee for treatment members

    If you want bloodwork to track your progress, book a Quest visit near you without the usual visit fee.

  • “I don't have time for clinic visits.”

    Care from your couch

    Assessment, clinician review and dose changes happen online, with no waiting room.

Tirzepatide + B12 vial and carton

28-day supply

$42.25/week

Billed $169 every 4 weeks

  • $20 review refunded if not prescribed
  • Cancel anytime
  • Full refund before your blood draw

Free, discreet shipping

Start my $20 doctor visit

Start today: your clinician reviews within 24 hours, and your first supply ships 2 to 5 business days after approval.

Labs we cover

Metabolic Check

  • CMP
  • HbA1c
  • Fasting insulin
  • HOMA-IR

Start or transfer your treatment between Nov 1 and Jan 31 and get this panel free at your 3-month mark. Labs are a bonus, not needed to start treatment.

From first question to first dose

Stubborn weight is often appetite signals and insulin that stopped working in your favor. Tirzepatide copies two gut hormones, GIP and GLP-1. Together they slow how fast your stomach empties, quiet hunger and help your body respond to insulin. Our version adds glycine, to help reduce muscle loss during weight loss, and vitamin B12, to help reduce fatigue and maintain vitamin levels. Those additions were not tested in the trials.

  1. 1
    Step 1
    A Black woman in her mid 40s with natural curls preparing a fresh, balanced meal

    Answer a few questions

    Weight history, goals, conditions and medicines, in a short online assessment.

  2. 2
    Step 2
    Online consultation with a licensed clinician

    A licensed clinician reviews you

    They check that tirzepatide fits and set your starting dose. Reviewed within 24 hours.

  3. 3
    Step 3
    A plain kraft parcel with a blank cold-chain label on an entry bench by an open door

    Your vial ships from a US pharmacy

    If prescribed, it arrives free in plain packaging in 2 to 5 business days.

  4. 4
    Step 4
    A couple relaxing together at home in the evening

    First dose at home

    The first four weeks use the lowest dose, so your body can adjust before the dose steps up.

  5. 5
    Step 5
    A South Asian woman in her early 50s with a silver streak in her hair on a video visit with her clinician at home

    Check in and step up

    Your clinician adjusts your dose with you, and you message your care team whenever you need.

Two women browsing flowers at an outdoor market

What to expect

  1. 01

    Weeks 1 to 4

    You start at the lowest dose. Hunger and portions often shrink first; the scale can lag.

  2. 02

    Months 2 to 5

    Your clinician raises the dose in small steps, at least four weeks apart. Nausea is most likely right after a step, and smaller, slower meals help.

  3. 03

    Months 5 to 18

    Weight keeps coming down. In the main trial the dose stepped up over 20 weeks and the average kept falling through week 72.

  4. 04

    After that

    Weight tends to return if treatment stops, so you and your clinician plan the long game together.

What makes it work better

Three things you can do alongside your treatment.

  1. Two people stretching outdoors
    01

    Protect your muscle

    Bigger weight loss means more lean mass at stake. Protein at every meal and strength training two or more days a week help protect it, and muscle also helps clear blood sugar.

  2. Walking up old stone steps
    02

    Break up your sitting

    Long stretches of sitting go with a larger waist and more abdominal fat. Stand or walk every 30 minutes or so, and aim for 150 to 300 minutes of moderate movement a week.

  3. A South Asian man in his late 30s preparing a fresh, balanced meal
    03

    Check the markers behind the scale

    Stubborn weight often traces back to insulin resistance. Our clinicians look at HbA1c (optimal 4.6 to 5.3%), triglycerides (optimal 50 to 80 mg/dL) and vitamin B12 (optimal 545 to 1100 pg/mL).

How compounded tirzepatide compares

FeatureOur tirzepatide + B12FDA-approved tirzepatideOur semaglutide + B12
How it worksCopies two gut hormones, GIP and GLP-1The two-hormone signal, studied in the trials shownCopies one gut hormone, GLP-1
What is in the vialTirzepatide with glycine and B12TirzepatideSemaglutide with glycine and B12
Starting dose2.5 mg once a week for four weeks2.5 mg once a week for four weeks, per the label0.25 mg once a week for four weeks
Regulatory statusCompounded, not FDA approvedFDA approved for chronic weight managementCompounded, not FDA approved
EvidenceTrial data is for the branded drug, not this preparationStudied directly in the trials shownTrial data is for the branded drug, not this preparation
Getting itOnline review, ships from a US pharmacyPrescription filled at a retail pharmacyOnline review, ships from a US pharmacy

We offer tirzepatide and semaglutide. Your clinician recommends one from your history.

Before you start

  • Usually prescribed at a BMI of 30 or more, or 27 or more with a weight-related condition. A clinician decides.
  • Not for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2, or who is pregnant.
  • Tell your clinician about pancreatitis, gallbladder disease, kidney problems, diabetes medicines or diabetic eye disease.
  • Take birth control pills? The FDA-approved tirzepatide label says to switch to a non-pill method or add a barrier method for 4 weeks after you start and after each dose increase.

How to take it

Inject under the skin once a week, on the same day each week. The first four weeks use 2.5 mg (25 units on the syringe). Your clinician then raises the dose in 2.5 mg steps, at least four weeks apart, to the lowest dose that works for you, and does not step up while side effects are active.

Side effects and safety

Tirzepatide caused thyroid C-cell tumors in rats. Whether that happens in people is not known.

Tell your care team straight away if you feel a lump or swelling in your neck, your voice goes hoarse or swallowing becomes hard, you get severe stomach pain that will not stop, you cannot keep up with vomiting or diarrhea, you get pain in your upper right belly or your eyes turn yellow, or you get a rash with swelling of the face or lips or trouble breathing.

Common side effects

  • nausea
  • diarrhea
  • vomiting
  • constipation
  • abdominal pain
  • indigestion
  • injection site reactions
  • fatigue
  • hair loss

Rare but serious

  • acute pancreatitis
  • gallbladder disease
  • kidney injury from fluid loss
  • low blood sugar
  • worsening diabetic eye disease
  • food left in the stomach during anesthesia

Do not take this if you or a family member has had medullary thyroid carcinoma, you have Multiple Endocrine Neoplasia syndrome type 2, or you have reacted badly to tirzepatide before.

This is not a complete list of side effects. Message your care team about any symptom that worries you. What we dispense is a compounded preparation made by a licensed US pharmacy. Compounded medications are not approved by the FDA for safety, efficacy or quality.

Common questions

A white man in his early 50s with a salt-and-pepper beard reading a message from his care team
Is compounded tirzepatide FDA approved?+

No. Compounded medicines are not FDA approved, and FDA does not review them for safety, effectiveness or quality. Ours is made by a licensed US pharmacy on a clinician's prescription and includes glycine and B12. The trial results on this page are for the branded drug.

How is tirzepatide different from semaglutide?+

Tirzepatide acts on two gut hormone receptors, GIP and GLP-1, while semaglutide acts on GLP-1 only. In a head-to-head trial of the branded drugs, more weight was lost on tirzepatide. That trial was open-label, and stomach side effects were the most common problem on both.

How fast will the weight come off?+

You start at the lowest dose and your clinician raises it in small steps, so the early weeks are about tolerating it. In the main trial the dose stepped up over 20 weeks, and weight kept falling through the 72 weeks.

Who can take it?+

Usually adults with a BMI of 30 or more, or 27 or more with a weight-related condition, after a clinician reviews their history. It is not for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2.

What are the side effects?+

In the FDA-approved tirzepatide label, nausea affected 25% to 29% of people on the drug and 8% on placebo, with diarrhea, vomiting and constipation next. They are worst after a dose increase. Rare serious effects include pancreatitis and gallbladder disease.

What happens if I stop?+

Weight tends to come back. In a trial where people switched to placebo after 36 weeks, they regained an average of 14% of their body weight over the next year, while those who kept going lost more. Plan any change with your clinician.

Can I take it if I might get pregnant?+

Not during pregnancy. Tell your clinician if you are pregnant, breastfeeding or planning a pregnancy. If you take birth control pills, the FDA-approved tirzepatide label says to use a non-pill method or add a barrier method for 4 weeks after starting and after each increase.

What if I am not prescribed?+

The clinician review charge is refunded if you are not prescribed, and nothing ships.

The Two-Hormone Weight Plan

  • Reviewed by a US-licensed clinician, and prescribed only if it suits you
  • Filled by a licensed US pharmacy
  • Free, discreet shipping to your door
  • LegitScript certified, and rated 4.5 on Google

$42.25/week · Billed $169 every 4 weeks

Start my $20 doctor visit
  • $20 review refunded if not prescribed
  • Cancel anytime
  • Full refund before your blood draw
  • Free, discreet shipping
A Latina woman in her mid 50s with wavy dark hair on a video visit with her clinician at home

$42.25/week

Billed $169 every 4 weeks

Start $20 visit

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