Compounded semaglutide with glycine and B12: a weekly injection that quiets appetite and supports steady weight loss alongside food and movement changes. Prescribed after a licensed clinician reviews your history.
A weekly injection that quiets appetite and trims your waist, with B12 in every dose. Prescribed if it fits.
$39.25/weekBilled $157 every 4 weeks
Medication is charged only if your clinician prescribes it.
Every 28 days
$39.25/week
Free shipping with prescribed treatment.
Today you only pay a $20 clinician review, refunded if you’re not prescribed. Your plan starts only if prescribed.
Prescribed only if appropriate · Compounded medications are not FDA-approved.
14.9%
average body weight lost at 68 weeks on branded semaglutide 2.4 mg, vs 2.4% on placebo
Source: Wilding JPH, et al. STEP 1, N Engl J Med 2021;384(11):989-100286%
lost at least 5% of their body weight by week 68 on branded semaglutide, vs 32% on placebo
Source: Wilding JPH, et al. STEP 1, N Engl J Med 2021;384(11):989-10021 in 2
lost 15% or more of their body weight by week 68, vs about 1 in 20 on placebo
Source: Wilding JPH, et al. STEP 1, N Engl J Med 2021;384(11):989-100213.5 cm
average waist reduction at week 68 on branded semaglutide, vs 4.1 cm on placebo
Source: Wilding JPH, et al. STEP 1, N Engl J Med 2021;384(11):989-1002, Table 2Results from STEP 1, a trial of FDA-approved semaglutide 2.4 mg in adults without diabetes, with diet and activity support. Our semaglutide is compounded by a licensed US pharmacy, includes glycine and B12, is not FDA approved and was not studied in this trial. Individual results vary.
Average body weight lost: Day 1 0%, Week 20 10.6%, Week 68 17.4%
Source: Rubino D, et al. STEP 4, JAMA 2021;325(14):1414-25 (branded semaglutide 2.4 mg, continued group) · Group average in a trial of adults who reached the full dose at week 20 and kept taking it. Not a prediction for you.
Less food noise and steady weight loss, with B12 and glycine already in the vial and a clinician who steps your dose up for you.
Licensed clinician review
A US-licensed clinician reads your history, goals and medicines, and prescribes only if semaglutide fits.
Your prescription, filled
Compounded semaglutide with glycine and B12, made by a licensed US pharmacy and sent in 28-day supplies.
Free, discreet shipping
Plain packaging to your door, 2 to 5 business days after approval.
Dose steps built in
Your clinician moves your dose up gradually, at least four weeks apart, and each supply matches your current dose.
Your care team on message
Ask about nausea, appetite or your next step at any point, and your clinician can change the plan.
Tirzepatide on the table too
We offer both medicines, so your clinician can recommend the one that fits your history.
Free lab panel at month 3
Metabolic Check, as a progress check.
“GLP-1s leave me tired, and I don't want to lose muscle.”
B12 and glycine in every dose
Added by the prescriber to help reduce fatigue and muscle loss during weight loss, with nothing extra to buy or remember.
“I'd like numbers, not just the scale.”
No lab visit fee for treatment members
If you want bloodwork to track your progress, book a Quest visit near you without the usual visit fee.
“I don't have time for clinic visits.”
Care from your couch
Assessment, clinician review and refills of your plan happen online, with no waiting room.
Metabolic Check
Weight that won't budge is often hormones and habits, not willpower: appetite signals that stopped working and insulin that has to work harder. Semaglutide copies GLP-1, a hormone your gut releases after eating. It slows how fast your stomach empties and tells your brain you are full, so you eat less without white-knuckling it. Our version adds glycine, to help reduce muscle loss during weight loss, and vitamin B12, to help reduce fatigue and maintain vitamin levels. Those additions were not tested in the trials.
Weight history, goals, conditions and medicines, in a short online assessment.
They check that semaglutide fits and set your starting dose. Reviewed within 24 hours.
If prescribed, it arrives free in plain packaging in 2 to 5 business days.
The first four weeks use the lowest dose, so your body can adjust before the dose steps up.
Your clinician adjusts your dose with you, and you message your care team whenever you need.
You start at the lowest dose. Hunger and portions often shrink first; the scale can lag.
Your clinician steps the dose up, at least four weeks apart. Nausea is most likely right after a step, and smaller, slower meals help.
Weight keeps coming down. In the semaglutide trial the average kept falling until about week 60.
Weight tends to return if treatment stops, so you and your clinician plan the long game together.
Three things you can do alongside your treatment.
Some lean mass is lost with any weight loss. Protein at every meal and strength training two or more days a week help protect it, and muscle also helps your body clear blood sugar.
In a study of about 7,500 adults, better eating and more activity each shrank visceral fat, and doing both shrank it more. Aim for 150 to 300 minutes of moderate movement a week.
Weight that won't move often traces back to insulin resistance. Our clinicians look at HbA1c (optimal 4.6 to 5.3%), triglycerides (optimal 50 to 80 mg/dL) and vitamin B12 (optimal 545 to 1100 pg/mL).
| Feature | Our semaglutide + B12 | FDA-approved semaglutide 2.4 mg | Our tirzepatide + B12 |
|---|---|---|---|
| How it works | Copies the gut hormone GLP-1 to quiet appetite | Same hormone signal, studied in the trials shown | Copies two gut hormones, GIP and GLP-1 |
| What is in the vial | Semaglutide with glycine and B12 | Semaglutide | Tirzepatide with glycine and B12 |
| Starting dose | 0.25 mg once a week for four weeks | 0.25 mg once a week for four weeks, per the label | 2.5 mg once a week for four weeks |
| Regulatory status | Compounded, not FDA approved | FDA approved for chronic weight management | Compounded, not FDA approved |
| Evidence | Trial data is for the branded drug, not this preparation | Studied directly in the trials shown | Trial data is for the branded drug, not this preparation |
| Getting it | Online review, ships from a US pharmacy | Prescription filled at a retail pharmacy | Online review, ships from a US pharmacy |
We offer semaglutide and tirzepatide. Your clinician recommends one from your history.
Inject under the skin once a week, on the same day each week. The first four weeks use 0.25 mg (5 units on the syringe). Your clinician then steps the dose up in stages, at least four weeks apart, to the lowest dose that works for you, and holds it if side effects are significant.
Semaglutide caused thyroid C-cell tumors in rodents. Whether that happens in people is not known.
Tell your care team straight away if you feel a lump or swelling in your neck, your voice goes hoarse or swallowing becomes hard, you get severe stomach pain that will not stop, you cannot keep fluids down, you get pain in your upper right belly or your eyes turn yellow, or your face, lips or tongue swell.
Do not take this if you or a family member has had medullary thyroid carcinoma, you have Multiple Endocrine Neoplasia syndrome type 2, or you have reacted badly to semaglutide before.
This is not a complete list of side effects. Message your care team about any symptom that worries you. What we dispense is a compounded preparation made by a licensed US pharmacy. Compounded medications are not approved by the FDA for safety, efficacy or quality.
No. Compounded medicines are not FDA approved, and FDA does not review them for safety, effectiveness or quality. Ours is made by a licensed US pharmacy on a clinician's prescription and includes glycine and B12. The trial results on this page are for the branded drug.
Appetite usually changes first, and the scale follows. You start at the lowest dose and step up slowly, so the early weeks are about tolerating it. In the main trial the average kept falling until about week 60.
Semaglutide for weight is usually prescribed at a BMI of 30 or more, or 27 or more with a weight-related condition. A clinician reviews your history and decides. It is not for anyone with a personal or family history of medullary thyroid carcinoma or MEN 2.
In the semaglutide 2.4 mg label, nausea affected 44% of people on the drug and 16% on placebo, with diarrhea, vomiting, constipation and stomach pain next. They are worst after a dose increase. In STEP 1, 4.5% stopped because of stomach effects, vs 0.8% on placebo. Rare serious effects include pancreatitis and gallbladder disease.
Weight tends to come back. In a follow-up of STEP 1, people regained about two-thirds of the weight they had lost within a year of stopping. That is why we plan the next step with you rather than stopping suddenly.
Not during pregnancy. The semaglutide 2.4 mg label says to stop at least 2 months before a planned pregnancy, because the drug stays in your body a long time. Tell your clinician if you are pregnant, breastfeeding or planning a pregnancy.
Both are weekly injections. Tirzepatide acts on two gut hormones instead of one, and branded tirzepatide beat branded semaglutide in a head-to-head trial. Your clinician recommends one based on your history, goals and how you tolerate treatment.
The clinician review charge is refunded if you are not prescribed, and nothing ships.
$39.25/week · Billed $157 every 4 weeks
