For low desire that bothers you. An as-needed option that works in the brain, not on blood flow.
$73.17/moBilled $439 every 168 days
Medication is charged only if your clinician prescribes it.
Start with a $20 clinician review
21% to 3%
nausea after the first dose, then after later doses, in the trials of the injected form
Source: Vyleesi prescribing information, section 6.112%
of US women report a sexual problem that causes them personal distress, peaking at ages 45 to 64
Source: Shifren JL, et al. Obstet Gynecol 2008;112(5):970-8 (PRESIDE)1,267
premenopausal women took part in two 24-week, placebo-controlled phase 3 trials of the injected form
Source: Kingsberg SA, et al. Obstet Gynecol 2019;134(5):899-908 (RECONNECT)+0.35
points on the 1.2 to 6 desire scale vs placebo, with distress down 0.33 (both significant)
Source: Kingsberg SA, et al. Obstet Gynecol 2019;134(5):899-908 (RECONNECT)Trials of Vyleesi, the FDA-approved injection, in premenopausal women with acquired, generalized low desire. Compounded PT-141 is not FDA approved and was not studied. Individual results vary.
A desire-first option, screened for your blood pressure and heart health, delivered privately and used only when you choose.
Licensed clinician review
A US-licensed clinician screens your blood pressure, heart history and medicines before prescribing.
Prescription PT-141 injection
Compounded and dispensed by a licensed US pharmacy, in an 84 or 168 day supply.
Free, plain-packaged shipping
Ships 2 to 5 business days after approval.
Care-team messaging
Ask about timing, nausea and dose, and your clinician can adjust your plan.
Free lab panel at month 3
Biological Age Reveal, as a progress check.
“Is this safe for me?”
Screened before you start
Blood pressure and heart history are checked first, and the review fee is refunded if you are not prescribed.
“What if I feel sick?”
A first-dose plan
Your care team helps you time the first dose, the one most likely to cause nausea.
“I do not want to explain this in person.”
No appointment, no waiting room
Questions online, review within 24 hours, vial at your door.
Biological Age Reveal
ED tablets work on blood flow once you are already aroused. PT-141 is a melanocortin receptor agonist, and the receptors it activates sit in the brain as well as the skin. The FDA label says how it improves desire in women is not known, so we do not claim a precise mechanism.
The only large trials were in premenopausal women with low desire, and that is the one FDA-approved use. For men, use is off-label and the research is small and early. Your clinician will say that plainly before prescribing.
Desire is shaped by more than one medicine. Stress, sleep, mood, thyroid, hormones and other medicines all matter, which is why the review starts with your history.
One dose, at least 45 minutes ahead. Used only when you want it, never more than once in 24 hours or eight times in a month.
Desire, distress, relationship, health history and blood pressure.
They check blood pressure and heart history and explain dosing.
A small injection at least 45 minutes before sex. Not daily.
Tell your care team how it is working and about any nausea.
Plan it for a quiet evening at home. Nausea is the most common effect and is most likely with this first one.
Inject at least 45 minutes before sex, not at the last minute. You set the mood rather than the clock.
Blood pressure can rise briefly and your heart rate dip slightly. Rest, and message your care team about a severe headache or chest pain.
One dose in 24 hours and no more than 8 a month. If nothing improves after about 8 weeks, talk to your clinician about whether to continue.
Three things you can do alongside your treatment.
Low mood, anxiety, thyroid conditions and some medicines all pull desire down, and low testosterone can too in men. Ask your clinician about checking thyroid and hormones before you rely on any injection.
Chronic stress keeps cortisol high and desire low. Time outdoors, a walk, slow breathing and steady sleep are low-cost ways to shift it.
Long sitting is linked to poorer metabolic health, and strength and movement protect it. More energy and a body that feels like yours is part of wanting sex.
| Feature | PT-141 injection | Daily pill for low desire (flibanserin) |
|---|---|---|
| When you take it | As needed, at least 45 minutes before | Every day, at bedtime |
| How it is taken | Small injection under the skin | Tablet |
| Status | Compounded, not FDA approved; the brand Vyleesi is approved | FDA-approved brand (Addyi) |
Compounded PT-141 is not FDA approved. Your clinician helps you choose.
Inject 0.1 to 0.175 mL (1 to 1.75 mg) under the skin of the abdomen or thigh, as needed, at least 45 minutes before sex. Your clinician sets your dose; the pharmacy label shows it in units.
Do not use more than one dose in 24 hours, or more than 8 doses a month.
Bremelanotide is FDA approved only for low sexual desire in premenopausal women. The label states it is not indicated in postmenopausal women, not in men, and not to enhance sexual performance.
Tell your care team straight away if your blood pressure climbs or you get a severe headache after a dose, you cannot stop vomiting, you notice new dark patches on your face, gums or breasts, you get chest pain, or your heartbeat becomes very slow.
Common side effects
Rare but serious
Do not take this if you have high blood pressure that is not controlled, or you have known heart disease.
This is not a complete list of side effects. Message your care team about any symptom that worries you. What we dispense is a compounded preparation made by a licensed US pharmacy. Compounded medications are not approved by the FDA for safety, efficacy or quality.
Sildenafil helps blood flow. PT-141 is a melanocortin receptor agonist that acts in the brain, and it was studied for low desire.
In the brand trials, 40% had nausea at some point, but it was highest after the first dose (21%) and about 3% after later doses. Taking an anti-nausea pill beforehand did not reduce it in a brand study.
Briefly. The brand label reports a rise of up to 6 points systolic, usually gone within 12 hours. It is not for uncontrolled high blood pressure or heart disease.
No more than once in 24 hours, and the brand label does not recommend more than 8 doses a month. It says to stop after 8 weeks if there is no improvement.
Dark patches on the face, gums or breasts were reported by 1% in brand trials using up to 8 doses a month, and more often with daily use. Resolution was not confirmed in some. Do not dose daily.
The brand label is for premenopausal women and says it is not indicated after menopause. Use after menopause would be off-label, so tell your clinician where you are.
Ours is not. The FDA-approved bremelanotide, Vyleesi, is an injection for premenopausal women. Ours is compounded by a licensed US pharmacy.
168-day supply · $73.17/mo · Billed $439 every 168 days