The same desire medicine as the PT-141 injection, in a needle-free nasal spray.
$73.17/moBilled $439 every 168 days
Medication is charged only if your clinician prescribes it.
Start with a $20 clinician review
21% to 3%
nausea after the first dose, then after later doses, in the trials of the injected form
Source: Vyleesi prescribing information, section 6.112%
of US women report a sexual problem that causes them personal distress, peaking at ages 45 to 64
Source: Shifren JL, et al. Obstet Gynecol 2008;112(5):970-8 (PRESIDE)1,267
premenopausal women took part in two 24-week, placebo-controlled phase 3 trials of the injected form
Source: Kingsberg SA, et al. Obstet Gynecol 2019;134(5):899-908 (RECONNECT)+0.35
points on the 1.2 to 6 desire scale vs placebo, with distress down 0.33 (both significant)
Source: Kingsberg SA, et al. Obstet Gynecol 2019;134(5):899-908 (RECONNECT)Trials of Vyleesi, the FDA-approved injection, in premenopausal women with acquired, generalized low desire. Compounded nasal PT-141 is not FDA approved and was not part of those trials. Individual results vary.
A desire-first option with no needle, screened for your blood pressure and heart health, delivered privately and used only when you choose.
Licensed clinician review
A US-licensed clinician screens your blood pressure, heart history and medicines before prescribing.
Prescription PT-141 nasal spray
Compounded and dispensed by a licensed US pharmacy, in an 84 or 168 day supply.
Free, plain-packaged shipping
Ships 2 to 5 business days after approval.
Care-team messaging
Ask about timing, nausea and dose, and your clinician can adjust your plan.
Free lab panel at month 3
Biological Age Reveal, as a progress check.
“I do not want to give myself an injection.”
No needle
One spray in each nostril, nothing to inject.
“Is this safe for me?”
Screened before you start
Blood pressure and heart history are checked first, and the review fee is refunded if you are not prescribed.
“I do not want to explain this in person.”
No appointment, no waiting room
Questions online, review within 24 hours, spray at your door.
Biological Age Reveal
Bremelanotide activates melanocortin receptors, including ones in the brain. The FDA label says how it improves desire in women is not known, so we do not claim a precise mechanism. It is a different route from ED tablets, which work on blood flow.
The large trials used an injection in premenopausal women, and that is the only FDA-approved form. Our nasal spray gives the same medicine by a different route. Early studies of a nasal form were small, so we say plainly that the evidence for the spray is thinner.
Desire is shaped by more than one medicine. Stress, sleep, mood, thyroid, hormones and other medicines all matter, which is why the review starts with your history.
One spray, at least 45 minutes ahead. The same medicine without an injection. Never more than one dose in 24 hours.
Desire, distress, health history and blood pressure.
They check blood pressure and heart history.
Use as directed, ahead of time, only when you want to.
Tell your care team how it is working.
Plan it for a quiet evening at home. Nausea is the most common effect and is most likely with this first one.
Use it at least 45 minutes before sex, not at the last minute. You set the mood rather than the clock.
Blood pressure can rise briefly and your heart rate dip slightly. Rest, and message your care team about a severe headache or chest pain.
One dose in 24 hours and no more than 8 a month. If nothing improves after about 8 weeks, talk to your clinician about whether to continue.
Three things you can do alongside your treatment.
Low mood, anxiety, thyroid conditions and some medicines all pull desire down, and low testosterone can too in men. Ask your clinician about checking thyroid and hormones first.
Chronic stress keeps cortisol high and desire low. Time outdoors, a walk, slow breathing and steady sleep are low-cost ways to shift it.
Long sitting is linked to poorer metabolic health, and strength and movement protect it. More energy and a body that feels like yours is part of wanting sex.
| Feature | Nasal spray | Injection |
|---|---|---|
| Needle | No | Small under-the-skin injection |
| FDA-approved form exists | No; nasal use is compounded only | Yes (Vyleesi), though ours is compounded |
| Use | As needed | As needed |
Both of our PT-141 forms are compounded and not FDA-approved.
Spray once in each nostril (2 mg total) at least 45 minutes before sex. Do not use more than one dose in 24 hours, or more than 8 doses a month.
Bremelanotide is FDA approved only for low sexual desire in premenopausal women. The label states it is not indicated in postmenopausal women, not in men, and not to enhance sexual performance.
Tell your care team straight away if your blood pressure climbs or you get a severe headache after a dose, you cannot stop vomiting, you notice new dark patches on your face, gums or breasts, you get chest pain, or your heartbeat becomes very slow.
Common side effects
Rare but serious
Do not take this if you have high blood pressure that is not controlled, or you have known heart disease.
This is not a complete list of side effects. Message your care team about any symptom that worries you. What we dispense is a compounded preparation made by a licensed US pharmacy. Compounded medications are not approved by the FDA for safety, efficacy or quality.
Nasal PT-141 has not been studied in the trials behind the FDA-approved injection, so we cannot compare them. Your clinician sets your dose.
With the injected form, nausea was highest after the first dose (21%) and about 3% after later doses. Experience with the spray may differ.
The injected form raised blood pressure briefly. It is not for uncontrolled high blood pressure or heart disease.
No more than once in 24 hours, and not daily.
Dark patches were reported with the injected form, more often with daily use. Avoid daily dosing.
Anyone with uncontrolled high blood pressure, known heart disease, or who is pregnant.
168-day supply · $73.17/mo · Billed $439 every 168 days