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Methylcobalamin (B12) 5 mg/mL injection vial package

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Vitamin B12 Injection

Injection · 5 mg/mL methylcobalamin

Low B12, fixed at the source. A weekly methylcobalamin injection that skips your gut.

$11.90/weekBilled $119 every 70 days

Start my $20 doctor visit

Medication is charged only if your clinician prescribes it.

US clinicians
Licensed pharmacy
LegitScript
$20 review refunded
Free discreet shipping

A weekly injection that skips gut absorption
Methylcobalamin 5 mg/mL, one vial covers 70 days
Dose reviewed and adjusted by your clinician

70-day supply

$11.90/week

Billed $119 every 70 days · Cancel anytime

Injection · 5 mg/mL methylcobalamin
Free, discreet shipping
Prescribed only if appropriate

Start with a $20 clinician review

The review fee is refunded if you’re not prescribed. Medication is billed separately only if prescribed.

Start my $20 doctor visit

Prescribed only if appropriate. Compounded medications are not FDA-approved. Review the full terms in checkout.

What the research shows

19.1% vs 9.5%
had low or borderline-low B12 after 5 years on metformin vs placebo, in about 1,700 adults from a randomized trial
Source: Aroda VR, et al. J Clin Endocrinol Metab 2016;101(4):1754-61 (Diabetes Prevention Program Outcomes Study)
65% higher
odds of B12 deficiency after 2 or more years on a proton pump inhibitor, in a study of 25,956 people with deficiency
Source: Lam JR, et al. JAMA 2013;310(22):2435-42
2 to 3%
of US adults have a B12 deficiency, and the risk rises with age, metformin and acid-reducing drugs
Source: Patel H, McGuirk R. Am Fam Physician 2025;112(3):294-300

Figures come from published studies of who runs low on B12. They describe the problem, not a result from our product. Ours is compounded methylcobalamin and was not studied in these trials. Individual results vary.

What the research measured

3.6%: Of US adults aged 19 and older fall below 200 pg/mL, the cutoff used to define deficiency in that survey
12.5%: Fall below 300 pg/mL, the level described as low or marginal status
203 to 813 pg/mL: The normal serum B12 range published by the NIH Office of Dietary Supplements

Thresholds and population figures from the NIH Office of Dietary Supplements Vitamin B12 Fact Sheet for Health Professionals, citing the National Health and Nutrition Examination Survey 2007 to 2018. ODS does not set one flat diagnostic cutoff, it notes that clinicians use values lower than 200 or 250 pg/mL, and 200 is the threshold that prevalence analysis used.

Read the source research

The Low-B12 Fix Plan

Bring a low B12 back into range with one injection a week at home, no matter what your gut or your medicines are doing to absorption.

Everything included

Licensed clinician review
A US-licensed clinician reads your history, your medicines (including metformin and acid reducers) and any B12 results you share, and prescribes only if injectable B12 fits.
Compounded methylcobalamin, 5 mg/mL
A 10 mL vial from a licensed US pharmacy. One fill covers 70 days at the listed directions.
A starting dose and a step up
The directions begin at 2.5 mg once a week and allow 5 mg after 2 weeks if you tolerate it. Your clinician can change the plan.
Free, discreet shipping
2 to 5 business days after your clinician approves a prescription.
Care-team messaging
Message your care team about side effects or dose. Your clinician adjusts the plan as you go.

Bonuses

Free lab panel at month 3
Biological Age Reveal, as a progress check.
“What if the first dose is not enough?”
Dose step-up built in
The prescription directions allow a move from 2.5 mg to 5 mg after 2 weeks if tolerated.
“Will my other medicines get in the way?”
A medicine-aware review
Your clinician looks at metformin, acid reducers and other medicines as possible causes, not just at the number.

Labs we cover

Biological Age Reveal

CMP
CBC with differential
hs-CRP
Biological age score

Start or transfer your treatment between Nov 1 and Jan 31 and get this panel free at your 3-month mark. Labs are a bonus, not needed to start treatment.

From a low B12 to a weekly injection

B12 from food has to be freed by stomach acid, bound to a carrier called intrinsic factor, then absorbed in the last stretch of the small intestine. Metformin, acid-reducing drugs, gastritis, celiac or Crohn's disease, weight-loss surgery and age can each break a link in that chain. A weekly injection goes under the skin and never touches it.

Serum B12 is the first check. When it sits in the borderline zone, methylmalonic acid (MMA) and homocysteine show whether your cells are short, because both build up when B12 runs low. The ranges our clinicians use are stricter than the lab cutoff for deficiency: B12 above about 545 pg/mL, MMA at or below 260 nmol/L, and homocysteine of 5.0 to 7.2 umol/L.

One injection a week. Injecting skips the gut, where B12 absorption most often breaks down.

Step 1
Tell us what you take and how you feel
Answer a few health questions online and share any recent B12, MMA or homocysteine results you have. Metformin and acid reducers are worth mentioning.
Step 2
A licensed clinician reviews you
They check your history and medicines and prescribe only if injectable B12 fits. Reviewed within 24 hours.
Step 3
Your vial ships from a US pharmacy
If prescribed, a 10 mL vial of methylcobalamin ships free in discreet packaging in 2 to 5 business days.
Step 4
Adjust as you go
One small injection under the skin each week. Repeat labs show whether B12 and MMA moved, and your clinician adjusts your dose.

A woman stretching her arm on a terrace by the sea

What to expect

Blood B12 climbs first
Levels rise quickly after injections. How you feel depends on how low you were.
If you were low
Energy and clearer thinking may follow. Nerve symptoms such as tingling take longer to settle.
If you were normal
Expect no change. Extra B12 has not been shown to add energy when levels are adequate.
Pink urine is normal
The excess leaves in your urine and is harmless.
Recheck
Repeat B12, MMA and homocysteine show whether your cells caught up, and your clinician adjusts your dose.

What makes it work better

Three things you can do alongside your treatment.

Find out why you are low
Eat B12 foods as well
Keep folate and homocysteine in view

Injection, high-dose pills or food

Feature	Our B12 injection	High-dose oral B12	Food and a multivitamin
How it gets in	Under the skin, past the stomach and gut	A small share is absorbed without the usual carrier, so doses are large	Needs stomach acid and intrinsic factor to work
What the evidence says	Injected B12 is the long-standing treatment for poor absorption; ours is methylcobalamin, which was not the form in most trials	In 3 small trials oral raised B12 as well as injections did (low-quality evidence); a 2025 review calls oral noninferior	Works for keeping up, not for correcting a deficiency on its own
Best for	Absorption problems, severe deficiency, nerve symptoms, or one weekly step	Most people with a mild to moderate shortfall	Staying in range once you are there
Format	One injection a week at home	A pill every day	Everyday meals
Regulatory status	Compounded, not FDA approved; prescribed only if appropriate	Supplement or prescription, depending on the product	Not applicable

Your clinician decides whether an injection fits. If pills would serve you as well, they will tell you.

Before you start

Tell your clinician every medicine you take. Metformin and acid reducers are common reasons for low B12.
Pregnant, breastfeeding or planning a pregnancy? Say so in your assessment. B12 needs go up and your clinician sets the plan.
Do not take B12 if you are sensitive to cobalt or to vitamin B12. Do not use folic acid in place of B12, because it can hide anemia while nerve damage progresses.
Never stop a prescribed medicine on your own. If you think a drug is lowering your B12, raise it with the clinician who prescribed it.
Methylcobalamin here is compounded by a licensed US pharmacy and is not FDA approved. It is prescribed only if it is right for you.

How to take it

Inject 50 units (2.5 mg) subcutaneously once weekly. May increase to 100 units (5 mg) if tolerated after 2 weeks, as directed by your clinician. Discard any remaining medication.

Side effects and safety

B12 injections made as cyanocobalamin are FDA approved for B12 deficiency from poor absorption, including pernicious anemia. What we dispense is compounded methylcobalamin, which is not FDA approved. Using B12 for energy when your levels are normal is off-label.

Tell your care team straight away if you get trouble breathing, throat swelling or hives after an injection, vision changes, chest tightness or leg swelling, muscle weakness, or an irregular heartbeat.

Common side effects

mild diarrhea
itching
rash
a reaction where the injection was given

Rare but serious

severe allergic reactions, which have been reported after injected B12
low potassium and heart rhythm problems when severe anemia is treated quickly
fluid on the lungs early in treatment
rapid worsening of vision in people with an inherited eye condition called Leber's disease

Do not take this if you are sensitive to cobalt or to vitamin B12. Do not use folic acid in place of B12, because it can hide anemia while nerve damage progresses.

This is not a complete list of side effects. Message your care team about any symptom that worries you. What we dispense is a compounded preparation made by a licensed US pharmacy. Compounded medications are not approved by the FDA for safety, efficacy or quality.

Read the source research

Your questions, answered.

Who actually benefits from B12 injections?

People whose B12 is low or borderline. Common reasons are long-term metformin, acid-reducing drugs, age, a plant-based diet, and gut conditions such as celiac or Crohn's disease. If your levels are already normal, more B12 is unlikely to change how you feel.

I am tired. Will B12 give me energy?

Only if low B12 is part of the reason. Reviews of the evidence find that B12 helps fatigue in people who are short on it, not in people who are replete. That is why a clinician reviews you first and why we suggest sharing any B12, MMA or homocysteine results.

Why an injection and not high-dose pills?

For many people pills work. In 3 small trials, high-dose oral B12 raised blood levels about as well as injections, and a 2025 review calls oral noninferior for most adults. Injections are usually preferred for severe deficiency, nerve symptoms or poor absorption, and some people simply prefer one weekly step.

What is the difference between methylcobalamin and cyanocobalamin?

Ours is methylcobalamin, one of the active forms. Approved B12 injections are cyanocobalamin, and most trials used that form. Cells convert B12 forms into the ones they need, and we are not aware of a head-to-head trial showing a clinical edge for either.

How and how often do I inject?

The directions are 50 units (2.5 mg) under the skin once a week. After 2 weeks your clinician may raise it to 100 units (5 mg) if you tolerate it. A 10 mL vial of 5 mg/mL covers 70 days. Your clinician adjusts the plan to you.

Which labs should I look at?

Serum B12 first. If it is borderline, methylmalonic acid (MMA) and homocysteine show whether your cells are actually short, because both rise when B12 runs low. The optimal ranges our clinicians use are B12 above about 545 pg/mL, MMA at or below 260 nmol/L and homocysteine of 5.0 to 7.2 umol/L.

Why is my urine pink afterwards?

B12 is a deep red compound and the excess leaves in your urine. A day or so of pink urine is expected and harmless.

Is it approved, and is it safe?

B12 injections made as cyanocobalamin are FDA approved for deficiency from poor absorption, including pernicious anemia. What we dispense is compounded methylcobalamin, which is not FDA approved or reviewed for safety, efficacy or quality. Common effects are mild diarrhea, itching, rash and soreness at the injection site. Rare serious ones include allergic reactions and low potassium when severe anemia is treated quickly.

The Low-B12 Fix Plan

Reviewed by a US-licensed clinician, and prescribed only if it suits you
Filled by a licensed US pharmacy
Free, discreet shipping to your door
LegitScript certified, and rated 4.5 on Google

70-day supply · $11.90/week · Billed $119 every 70 days

Start my $20 doctor visit

$20 review refunded if not prescribed
Cancel anytime
Free, discreet shipping

Vitamin B12 Injection

What the research shows

What the research measured

The Low-B12 Fix Plan

Everything included

Bonuses

Labs we cover

From a low B12 to a weekly injection

Tell us what you take and how you feel

A licensed clinician reviews you

Your vial ships from a US pharmacy

Adjust as you go

What to expect

Blood B12 climbs first

If you were low

If you were normal

Pink urine is normal

Recheck

What makes it work better

Find out why you are low

Eat B12 foods as well

Keep folate and homocysteine in view

Injection, high-dose pills or food

Before you start

How to take it

Side effects and safety

Your questions, answered.

The Low-B12 Fix Plan