--- title: "Tretinoin + Niacinamide Cream, Prescribed Online | Vitals Vault" description: "A compounded night cream pairing tretinoin, the most studied retinoid, with niacinamide to reduce the irritation retinoids usually cause. Used for texture, tone…" canonical: "https://www.vitalsvault.com/treatments/care-tretinoin-niacinamide" last-updated: 2026-08-22 --- # Tretinoin + Niacinamide Cream, Prescribed Online | Vitals Vault > A compounded night cream pairing tretinoin, the most studied retinoid, with niacinamide to reduce the irritation retinoids usually cause. Used for texture, tone… ![Tretinoin + Niacinamide topical cream package](https://static.vitalsvault.com/treatments/editorial/6acaeb75c0b874369ec190a2-lane61-care-tretinoin-niacinamide-cms-1200-82fbfae55eefd165.webp) # Tretinoin + Niacinamide Cream Topical Cream · Tretinoin + Niacinamide - Clearer skin and smoother texture - Niacinamide reduces irritation - One simple nightly step Choose your plan90-day supply$129 every 90 days$44.00/mo equivalent 180-day supply$229 every 180 days$39.00/mo equivalent Start with a $20.00 clinician review The review fee is refunded if you’re not prescribed. Medication is billed separately only if prescribed. [Start as a man](https://www.vitalsvault.com/checkout/medications/app?plan=f135f9ad-257a-4ec1-b307-1e99f21d587c&gender=male&flow=payment-first&skipWelcome=true&source=treatments)[Start as a woman](https://www.vitalsvault.com/checkout/medications/app?plan=f135f9ad-257a-4ec1-b307-1e99f21d587c&gender=female&flow=payment-first&skipWelcome=true&source=treatments) Prescribed only if appropriate. Compounded medications are not FDA-approved. Review the full terms in checkout. Licensed cliniciansFree shipping ## What does Tretinoin do? Tretinoin speeds up how quickly skin cells turn over, which clears blocked pores and, over months, improves texture and tone. It is the most studied ingredient in dermatology and also the most likely to irritate — which is why niacinamide is compounded alongside it and why you build up frequency slowly. ## What to expect - Start slowly — Two or three nights a week, building up over a couple of months. - Purging is common — The first four to six weeks often look worse before better. - Daily SPF is required — Not optional with a retinoid. - Months, not weeks — Texture and tone improve gradually. ### Your treatment Topical cream Your prescription confirms the strength, quantity and dispensing schedule. ### Your routine Applied as part of your prescribed skin-care routine. Follow your clinician’s instructions and the pharmacy label. ### Delivered discreetly Free shipping, in discreet packaging. Treatment ships only after your clinician approves a prescription. ### Clinician-guided care A plan reviewed around your health. Your clinician determines whether treatment is appropriate for you. Your selected plan 90-day supply $129 every 90 days Prescribed only if appropriate. Billing frequency and shipment quantity may differ; your prescription confirms what is dispensed. ## What you’ll notice ### Clearer skin Fewer breakouts and steadier tone. ### Matched to you Prescribed for your skin, not guessed at. ### Beyond the surface Everyday health that shows on your face. ### One daily step A routine that fits your morning. ## How it works 1. ![Online consultation with a licensed clinician](https://static.vitalsvault.com/treatments/editorial/vv-step-clinician-neutral-6719a9b7f7adcdf4.webp)Step 1 ### Online visit and review Answer a few health questions. A licensed clinician reviews them online. No waiting rooms. Reviewed within 72 hours 2. ![Prescription approved](https://static.vitalsvault.com/treatments/editorial/vv-hiw-step3-delivered-v1-2792b7b7fff611e1.webp)Step 2 ### Ships to your door If prescribed, your medication ships free and discreetly. 2–5 business days 3. ![Feeling the difference](https://static.vitalsvault.com/treatments/editorial/6abf4b26f77cea570a98e695-vv-step-outcome-skin-men-64549bf39f0ba8db.webp)Step 3 ### Feel the difference Your clinician checks in and adjusts your plan as you go. Ongoing support ## How to take it Apply a pea-sized amount to a clean, dry face at night, starting two to three nights a week and building up as tolerated ## Side effects and safety Tretinoin is FDA approved for acne. This preparation is compounded with niacinamide, so the combination has not been reviewed by the FDA. Tell your care team straight away if your skin blisters or crusts, you get severe swelling, burning or stinging you cannot tolerate, you get sunburned while using it, or peeling keeps getting worse. Common side effects - redness - peeling - dryness - burning - stinging - itching - irritated skin Rare but serious - irritation severe enough to stop treatment - increased sunburn risk - worsening of eczema-prone skin - a temporary flare of acne in the first weeks Do not take this if you are pregnant, or your skin is sunburned or has active eczema. This is not a complete list of side effects. Message your care team about any symptom that worries you. What we dispense is a compounded preparation made by a licensed US pharmacy. Compounded medications are not approved by the FDA for safety, efficacy or quality. ## Your questions, answered. Why start only two or three nights a week? Tretinoin irritates most in the first weeks. Building up frequency slowly is the difference between staying on it and giving up. Most people reach nightly use over a couple of months. Will my skin get worse before it gets better? Often, yes. Purging and flaking in the first four to six weeks is common and usually settles. Persistent raw or painful skin means backing off the frequency. Do I need sunscreen? Yes, daily. Tretinoin increases sun sensitivity, and sun exposure undoes the improvement you are working toward. Can I use it if I am pregnant or trying? No. Retinoids are contraindicated in pregnancy and while trying to conceive. ## Start your plan today 90-day supply · $129 every 90 days [Start as a man](https://www.vitalsvault.com/checkout/medications/app?plan=f135f9ad-257a-4ec1-b307-1e99f21d587c&gender=male&flow=payment-first&skipWelcome=true&source=treatments)[Start as a woman](https://www.vitalsvault.com/checkout/medications/app?plan=f135f9ad-257a-4ec1-b307-1e99f21d587c&gender=female&flow=payment-first&skipWelcome=true&source=treatments) ## The clinicians behind your care Your treatment is reviewed and prescribed by US-licensed clinicians in our network. ![Diana Kumar, MD, FACOG](https://static.vitalsvault.com/treatments/editorial/diana-kumar-md-c56d4b361d5774a7.webp) ### Diana Kumar, MD, FACOG Women's hormone health Board certified in obstetrics and gynecology and a Menopause Society Certified Practitioner. Works with members on perimenopause, menopause and hormone therapy. ![William Blackwell, MD](https://static.vitalsvault.com/treatments/editorial/william-blackwell-md-da493dcf19541ad1.webp) ### William Blackwell, MD Weight and metabolic health Board certified in emergency medicine and practicing telehealth since 2018. Focuses on weight management and metabolic health. ![Meenal Kheterpal, MD, FAAD](https://static.vitalsvault.com/treatments/editorial/kheterpal-md-faad-0719a17d75055313.webp) ### Meenal Kheterpal, MD, FAAD Dermatology Board certified dermatologist and Associate Professor of Dermatology at Duke University School of Medicine. Specializes in skin cancer and dermato-oncology. ![Shamail Tariq, MD](https://static.vitalsvault.com/treatments/editorial/shamail-tariq-md-18ac53212de5decd.webp) ### Shamail Tariq, MD Cardiometabolic health Board certified in cardiovascular disease and interventional cardiology. Focuses on preventive cardiology, blood pressure and cholesterol. ![Payel Gupta, MD](https://static.vitalsvault.com/treatments/editorial/payel-gupta-md-761421d304fefc01.webp) ### Payel Gupta, MD Allergy and immunology Triple board certified in allergy and immunology, internal medicine and pediatrics. Clinical instructor at the Icahn School of Medicine at Mount Sinai. --- Canonical HTML: https://www.vitalsvault.com/treatments/care-tretinoin-niacinamide - [llms.txt](https://www.vitalsvault.com/llms.txt) - [sitemap.xml](https://www.vitalsvault.com/sitemap.xml) - [Developer portal](https://www.vitalsvault.com/developers)